Evaluation of the Anticonvulsant and Antidepressant Effects of the Aqueous Extract of the Leaves of Ascotheca paucinervia (T. Anderson ex C.B. Clarke) Heine in Mice
Bassoueka D’Avila Judicaël
*
Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Technology, Marien Ngouabi University, BP: 69, Brazzaville, Congo.
Ondele Radar
Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Technology, Marien Ngouabi University, BP: 69, Brazzaville, Congo.
Omeka Ngassaki Gelvid
Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Technology, Marien Ngouabi University, BP: 69, Brazzaville, Congo.
Abena Ange Antoine
Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, BP: 69, Brazzaville, Congo.
*Author to whom correspondence should be addressed.
Abstract
The present study was undertaken to evaluate the anticonvulsant and antidepressant effects of Ascotheca paucinervia leaves on mice by using strychnine at 2.5mg/kg to induce convulsions and the forced swimming test to create a stressful situation, respectively. Concerning convulsions, only the 500mg/kg extract significantly increases (p<0.001) the time to onset of convulsions and it non-significantly reduces the duration of convulsions induced by strychnine. In addition, the extract reduces very significantly in a dose-dependent manner the time of immobility and it significantly increases the swimming time as well as the climbing time at both doses. At the same time, the estimation of the acute toxicity of the extract from the leaves of Ascotheca paucinervia according to guideline No. 425 of the OECD (2022) shows that the latter is weakly toxic and its LD50 is greater than 5000mg/kg. In addition, the evaluation of the sedative effect of this extract shows that it produces a dose-dependent sedative effects and at doses of 250m/kg and 500mg/kg, the extract significantly potentiates the sleep induced by phenobarbital. In summary, the results obtained suggest that Ascotheca paucineervia leaves extract possesses anticonvulsant and antidepressant effects.
Keywords: Anticonvulsant activity, antidepressant activity, epilepsy, Ascotheca paucinervia
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