Open Access Original Research Article

Herbal Medicines Used by Tuberculosis Patients in Myanmar

Soe Moe, Khin Saw Naing, Mila Nu Nu Htay

European Journal of Medicinal Plants, Page 1-10
DOI: 10.9734/EJMP/2018/37341

Aims: This study attempted to explore the natural products commonly used by the TB patients in a selected township of Myanmar.

Study Design: Secondary data analysis of qualitative data.

Methodology: This is a secondary data analysis of qualitative data focusing on the herbal plants used by the tuberculosis patients in Myanmar. A checklist was used for data analysis to explore the herbs used by TB patients and related information. The researcher also searched the literature using the both vernacular & botanical names of the herbs.

Results: Four herbal plants namely Lauk Thay (Desmodium triquetrum), Owe Pote (Melastoma malabathricum), Mu Yargyi (Justicia adhatoda) and Mee Quin Gamone (Rhoeo discolor) were identified in this study. There are two methods of administration of the herbal leaves. In several instances, the TB patients first make use of the herbs before seeking proper anti-TB treatment. Also, the patients and traditional healers alike accepted that the medicines provided by DOTS programme could cure the disease.

Conclusion: This study revealed that self-medication with herbs is a common practice among TB patients. As the herbal plants identified were well known medicinal plants in different parts of the world, their therapeutic value and efficacy should be further explored in the light of developing effective complimentary medicines for TB.

Open Access Original Research Article

Isolation and Anti-Bacterial Activity of the Active Components from the Stem- -Back of Enantial chlorantha

Ajisafe M. Peter, Akinnawo Solomon

European Journal of Medicinal Plants, Page 1-7
DOI: 10.9734/EJMP/2018/38174

A known quantity of coarsely blended stem-back of Enantia chlorantha was progressively extracted with hexane, ethyl acetate and ethanol respectively. The resulting crude extracts were separated into various components using thin layer chromatographic and preparative thin layer chromatographic techniques. The antibacterial activity of every isolated component was carried out using five test organisms which are Klebsiella pneumonia, Salmonel typhi, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.

The result of the antibacterial assay conducted indicated that some of the isolated components had significant activities against the test organisms employed.

Open Access Original Research Article

Effects of Hippophae rhamnoides L. Leaf and Marc Extract with Reduced Tannin Concentration on the Health and Growth Parameters of Newborn Calves

L. Liepa, E. Zolnere, I. Dūrītis, I. Krasnova, D. Segliņa

European Journal of Medicinal Plants, Page 1-11
DOI: 10.9734/EJMP/2018/38537

Aim: To study the effects of orally administered mixture of Hippophae rhamnoides leaf and marc extracts (HLM) on health parameters of newborn calves.

Study Design: Starting from birth day 0 (D0) till day 15 (D15) the extract of HLM was given orally to newborn calves before feeding them milk at an increased  dosage from 5 to 8 ml/calf/ two times a day  for prophylaxis of nutritional diarrhoea. The calves were clinically examined and weighed. Biochemical and morphological analyses of blood were determined.

Place and Duration of Study: Clinical institute, Faculty of Veterinary Medicine and the Institute of Horticulture at Latvia University of Agriculture, Jelgava, Latvia; within one year.

Methodology: HLM was prepared and chemically analysed.The control (C) and experimental (E) group - each consisted of 10 newborn calves. Clinical examination of calves was performed every day. Calves were weighed on D0, D15, D30, venous blood samples for biochemical and haematological analyses were collected on D1, D10, D15, D30. Data were analysed using software program SPSS 17.5.

Results: Tannin content decreased by 33.14% in HLM after addition of polyethylene glycol. In E, there was a better thermoregulation on D1. Diarrhoea incidence was fewer in E group (3 calves) than in C group (5 calves) and diarrhoea started later in E group (D6) compared to C group (D4). Daily weight gain on D0-D15 was significantly higher in E (473.1+/-35.0 g/day) than in C (386.6+/-36.9 g/day) (P= .05) and it correlated (r =- .625) with serum haptoglobin (Hpt) concentration. In E, Hpt significantly decreased on D10 and D15, compared with C. In E there was induced reduction of lymphocytes’ count in blood- on D30 it was 27.9±6.5 x109/μL (P< .01), lower than in C- 64±2.1 x109/μL.

Conclusion: HLM as feed additive can reduce diarrhoea incidences in calves, promote growth rate, reduce Hpt concentration and lymphocytes’ count in blood.

Open Access Original Research Article

Prophylactic and Curative Effects of Thymoquinone against CCL4-Induced Hepatotoxicity in Rats

H. Khither, W. Sobhi, A. Mosbah, M. Benboubetra

European Journal of Medicinal Plants, Page 1-8
DOI: 10.9734/EJMP/2018/38830

Background: Natural products from medicinal plants such as thymoquinone (TQ), the major compound derived from Nigella sativa L. Which has received considerable attention in recent years due to its diverse pharmacological properties, including antioxidant and anti inflammatory activities? The aim of this study is the investigation of prophylactic and curative effects of TQ against carbon tetrachloride (CCl4)-induced hepatotoxicity in male albino rats.

Materials and Methods: Hepatotoxicity was induced in rats by intraperitoneal administration of 3 ml/kg, 1:1 (V/V) mixture of CCl4 and olive oil both before and after treatment for 7 days with TQ. Prophylactic and curative effects of TQ were evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP).

Results: CCl4 administering by intraperitoneal injection led to significant (P<0.05) increase in serum transaminases (ALT and AST) and phosphatase (ALP) respectively compared with control animals. Thymoquinone showed significant (p<0.05) hepatoprotective activity by decreasing the activities of ALT, AST, ALP in both prophylactic and curative effects. These results revealed        that thymoquinone possesses significant hepatoprotective and hepatocurative effects against   CCl4-induced toxicity via its antioxidant and anti-inflammatory activities but the hepatocurative effect was the most effective.

Conclusion: Thymoquinone is a compound known for its pharmacological proprieties. We illustrated in this work, its important effect against hepatotoxicity induced by a toxic agent as CCL4 when it’s administrated in prophylactic or curative way.

Open Access Original Research Article

Antioxidant and Anti Cholinesterase Potential of Red Cabbage (Brassica oleracea var. capitata f. rubra)

J. Archana, M. P. Kusuma, Ch. Vijayabhargavi

European Journal of Medicinal Plants, Page 1-7
DOI: 10.9734/EJMP/2018/38169

Aim: This study aims at in-vitro evaluation of Red cabbage extracts for their antioxidant and anticholinesterase activity.

Methodology: Red cabbage collected from the local market was dried and extracted with different solvents. Qualitative and quantitative phytochemical screening of these extracts was done. Then the Resulting extracts were evaluated for antioxidant activity using DPPH and H2O2 scavenging at various concentrations. Anticholinesterase activity was assessed qualitatively using TLC autobiography.

Conclusions: Maximum antioxidant activity was found with methanolic extract and Maximum anticholinesterase activity is found with Hexane extract.