Open Access Original Research Article

Biochemical Defense against Die-Back Disease of a Traditional Medicinal Plant Mimusops elengi Linn.

Selima Khatun, Ugur Cakilcioglu, Manoranjan Chakrabarti, Suprakash Ojha, Narayan Chandra Chatterjee

European Journal of Medicinal Plants, Page 40-49
DOI: 10.9734/EJMP/2011/247

Mimusops elengi (Linn.) commonly known as Bakul is one such tree native to the Western Ghat region of the peninsular India. However, today this tree is also found growing in other parts of the tropical and sub tropical regions of the world. The stem, barks, leaves and fruits are used in various Ayurvedic and folk medications to treat various ailments. Die-back disease caused by Alternaria lunata severely affects the plants grown in and around Burdwan, West Bengal, India. An investigation was carried out to study the phenolics along with their oxidizing enzymes that involve in defense against the activity of the pathogen. Peroxidase activity reached its peak on 14th day after infection whereas polyphenol oxidase mediated phenol oxidation was increased upto 21st day in the infected tissues. The enhancement of phenols and their oxidizing enzymes in infected plants affords resistance of the host against die-back.

Open Access Original Research Article

Hypoglycemic and Wound Healing Properties of Cissus multistriata Leaf Extract in Rattus novergicus

Omale James, Yunus Habiburahman Ogirima

European Journal of Medicinal Plants, Page 50-59
DOI: 10.9734/EJMP/2011/252

The aim of this study was to investigate the anti-diabetic and wound healing properties of Cissus multistriata leaf extract. Diabetes mellitus was induced with alloxan and graded doses of methanol leaf extract of Cissus multistriata were administered orally to the experimentally diabetic rats for 28 days at 400, 800 and 1600mg/kg b.w for groups. Administration of the methanol extract elicited a statistically significant (P<0.05) reduction in blood glucose level in alloxan induced diabetic rats. The reduction was dose dependent. There was reduction in blood haemoglobin and increase in body weights of animals which were statistically significant (P<0.05) when compared with the control. Three groups of male rats each consisting of four rats were used for the evaluation of wound healing potential of the extract. Groups 1, 2 and 3 were treated topically with C. multistriata, Povidone iodine (drug) and paraffin base (negative control), respectively. The extract significantly (P<0.05) accelerated wound healing process compared to standard povidone iodine used. It could be stated that Cissus multistriata possesses hypoglycemic and wound healing properties.

Open Access Original Research Article

Inventory and Identification of Plants Used in the Treatment of Diabetes in Douala Town (Cameroon)

N. Din, S. D. Dibong, E. Mpondo Mpondo, R. J. Priso, N. F. Kwin, A. Ngoye

European Journal of Medicinal Plants, Page 60-73
DOI: 10.9734/EJMP/2011/273

Currently, the International Diabetes Federation estimates that 194 million people live with diabetes worldwide are 5.1% of the adult population and this number is estimated at 333 million in 2025. In Africa, there are about 13.6 million people suffering from diabetes. Despite many discoveries made about his treatment, cost of drug prescriptions is very high to justify the continued inaccessibility to medicine for the population living below a dollar daily income per person. The use of medicinal plants is accessible to all strata of society contributing to health for all. This study focuses on the inventory, identification and use of medicinal plants in the treatment of diabetes in Douala town. The ethnobotanical survey conducted in 2009 has enabled the identification of 41 plant species belonging to 36 genera and grouped into 26 families. These plants have led to the establishment of 47 medicinal recipes and some of which have already been cited by other authors. Ten species are common for the treatment of diabetes. These are: Alluim cepa, Aloe vera, Alstonia boonei, Catharanthus roseus, Costus afer, Cassia occidentalis, Ceiba pentandra, Citrus limon, Mangifera indica and Persea americana. The recipes which are more effective to apply every day are: one to two glasses of juice of Brassica oleracea L., a half glass of juice Phaseolus vulgaris L., three glasses of juice made from one to two handfuls of dry beard Zea mays L. boiled in a liter of water for 15 minutes and two glasses of boiled water with Eucalyptus sailgna Smith. Decoction and maceration are the main modes of preparation and oral mode is the only administration way met. The plants most used are harvested in forests, home gardens or crops and the organs used are the bark or leaf. Woody plants are most prevalent. Some plants are not recommended for pregnant women: Gynostemma pentaphyllum, Mormodica charantica, Panax ginseng, aloe vera because of the risk of miscarriage.

Open Access Original Research Article

Potentiality of Medicinal Plants in Treating Urinary Lithiasis in Littoral Region, Cameroon

Emmanuel NOUMI, Essoh Samuel EBWELLE

European Journal of Medicinal Plants, Page 74-87
DOI: 10.9734/EJMP/2011/234

Background: The objective of this study was to reveal patterns in the treatment of urinary lithiasis in the Littoral Region, Cameroon, based on data on the use of plants, from traditional healers and patients under primary health care, and to demonstrate the efficiency of some of the recipes used.
Methodology: An analysis of plants use data from semi-structured interviews with traditional healers was conducted and diagnostic data was collected from patients in the community. Health conditions were ranked according to the citation frequency of plant use reports to treat urinary calculus by healers.
Results: Plant use reports from 15 healers yielded about 22 medicinal plant species, which are used in 16 therapeutic preparations to treat urinary lithiasis conditions. The sample of the survey consisted of 30 patients, out of which 83.33% got well after an average of 2 months of treatment. People aged 50 to 60 years and married are the most affected by this illness. The region is situated on a volcanic soil and the richness in mineral elements would be a favorable factor to the formation of lithiasis. Furthermore, traditional health care in that region appears to be competent to overcome urinary calculus.
Conclusion: Traditional medicine in the study area is consistent with the local patterns of morbidity, health care needs in relation to the side effects of the soil richness in mineral elements.

Open Access Original Research Article

Phytochemical Screening and Biological Studies of the Leaves of Microtrichia perotitii DC (Asteraceae)

M. N. Abdullahi, H. Ibrahim, N. Ilyas

European Journal of Medicinal Plants, Page 88-97
DOI: 10.9734/EJMP/2011/188

The Butanolic soluble fraction (F3) of the leaves of Microtrichia perotitii DC was evaluated for its analgesic and anti-inflammatory effects on laboratory animals. The results of analgesic studies was dose dependent and showed significant inhibition of writhings in rats while those of the anti-inflammatory studies was dose independent and the values obtained were significantly different from the control (ketoprofene) at
P<0.5,P<0.01 and P≤0.001 under the student’s t-test. There were remarkable reductions of paw edema in the mice. The results of the biological studies expose the local usage of the leaves for the treatment of pains and inflammation. The phytochemical screening of the leaves revealed the presence of Saponins, Flavonones, Alkaloids and Tanins.

Open Access Original Research Article

Elevated Vanilmandelic Acid Concentration in Brain Tissue Following the Administration of Ethanolic Extract of Alstonia boonei (De Wild) in Rats

G. Oze, G. Onyeze, S. Abanobi, O. Ojiako, Obi Austin

European Journal of Medicinal Plants, Page 98-106
DOI: 10.9734/EJMP/2011/238

Vanilmandelic acid (VMA) is a common excretory metabolite of the catecholamines. The catecholamines are implicated in schizophrenic disorders, and in the regulation of sexual functions via the Hypothalamic Pituitary Axis (HTPA). Alstonia boonei stem bark extract is used extensively in folk medicine to treat malaria, mental disorders and some reproductive problems. The possible effect of the plant extract on the concentration of VMA was studied in rats using 50 and 200mg/kg for 2 and 4 weeks using Biosystem VMA test kit. The extract significantly (p< 0.05) elevated the brain concentration of VMA time and dose dependently. The histological study of the rat brain tissue (pituitary gland) revealed distortions of the tissue architecture in the treated groups. It is reasoned that catecholamines may play a role in the antipsychotic potential of the plant extract. Again the plant extract may have adverse effect on the CNS in the course of its application in folk medicine.