European Journal of Medicinal Plants https://journalejmp.com/index.php/EJMP <p style="text-align: justify;"><strong>European Journal of Medicinal Plants (ISSN: 2231-0894)</strong> is dedicated to publish&nbsp;high quality papers (<a href="/index.php/EJMP/general-guideline-for-authors">Click here for Types of paper</a>)&nbsp;in all areas of medicinal plants research including plant growth and development, agronomic management, plant nutrition, plant physiology, cell biology, molecular biology, biotechnology, medicinal properties, phytochemical constituents, fitoterapia, pharmacognosy, essential oils, ehnopharmacology and phytomedicine. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalejmp.com (European Journal of Medicinal Plants) contact@journalejmp.com (European Journal of Medicinal Plants) Thu, 13 Aug 2020 06:59:32 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 In vivo Antimalarial Activities of Five Ugandan Medicinal Plants on Plasmodium berghei in Mice https://journalejmp.com/index.php/EJMP/article/view/30300 <p><strong>Aim:</strong> Medicinal plants have played an important role in the treatment of different ailments including malaria in developing countries particularly in Africa. This study has evaluated the antimalarial activities of <em>Azadirachta indica</em> A. Juss (Meliaceae), <em>Cymbopogon citratus</em> Stapf. (Poaceae), <em>Moringa oleifera</em> Lam. (Moringaceae), <em>Tithonia diversifolia</em> (Hemsl) A. Grey (Asteraceae) and <em>Vernonia amygdalina</em> Del. (Asteraceae) which are commonly-used for malaria treatment in Uganda.</p> <p><strong>Study Design:</strong> This is an experimental laboratory report on antimalarial activities of some Ugandan medicinal plants for subsequent profiling in an herbal pharmacopoeia and eventual drug development.</p> <p><strong>Place and Duration of Study:</strong> The Animal Research Facility and the Clinical and Research Laboratory, Faculty of Medicine, Mbarara University of Science and Technology, Uganda, between July 2019 and March 2020.</p> <p><strong>Methodology:</strong> The antimalarial activity of the hot infusion of each leaf was evaluated on chloroquine-sensitive <em>Plasmodium berghei</em> ANKA-infected mice using 4-day test at 100 – 400 mg/kg with chloroquine (10 mg/kg) and artemether-lumefantrine (4 mg/kg) as positive controls; and distilled water as negative control. The observed haematological responses of the animals were determined with an automated haematometer.</p> <p><strong>Results:</strong> The results showed dose-dependent activities in the animals treated with the extract of each plant leaf in varying degrees. Thus, <em>V. amygdalina</em> and <em>T. diversifolia</em> showed the highest antimalarial activities with the chemosuppression values of 75% and 66% at 400 mg/kg, respectively. The results of <em>V. amygdalina, T. diversifolia</em> and <em>M. oleifera, </em>extracts gave the lowest ED<sub>50</sub> of 141, 195 and 231 mg/kg, respectively being significantly different from <em>A. indica</em> (ED<sub>50 </sub>319 mg/kg) and <em>C. citratus</em> (ED<sub>50 </sub>346 mg/kg) with <em>V. amygdalina</em> as the most potent extract among the five plant leaves.</p> <p><strong>Conclusion:</strong> The observed activities of the five plants have therefore supported their folkloric uses as antimalarial remedies by the Ugandan traditional medicine practitioners with obvious potentials for drug development.</p> Clement Olusoji Ajayi, Anthony Adebolu Elujoba, Hedmon Okella, Joseph Oloro, Atwine Raymond, Anke Weisheit, Casim Umba Tolo, Patrick Engeu Ogwang ##submission.copyrightStatement## https://journalejmp.com/index.php/EJMP/article/view/30300 Thu, 13 Aug 2020 00:00:00 +0000