https://journalejmp.com/index.php/EJMP/issue/feedEuropean Journal of Medicinal Plants2024-03-02T09:50:14+00:00European Journal of Medicinal Plantscontact@journalejmp.comOpen Journal Systems<p style="text-align: justify;"><strong>European Journal of Medicinal Plants (ISSN: 2231-0894)</strong> is dedicated to publish high quality papers (<a href="https://journalejmp.com/index.php/EJMP/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of medicinal plants research including plant growth and development, agronomic management, plant nutrition, plant physiology, cell biology, molecular biology, biotechnology, medicinal properties, phytochemical constituents, fitoterapia, pharmacognosy, essential oils, ehnopharmacology and phytomedicine. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p style="text-align: justify;"><strong>NAAS Score: 4.89 (2024)</strong></p>https://journalejmp.com/index.php/EJMP/article/view/1174Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats2024-02-13T12:47:49+00:00Akinwunmi Kemi Feyisayo kfarinde@yahoo.comSuleiman Aishat Toyin Obisakin Ayomiposi Blessing Famurewa Akindele Joshua <p>Caffeine is the most widely consumed psychoactive drug in the world. It is often marketed for its physical and cognitive performance benefits. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. The ingestion of potentially toxic amounts of caffeine in the forms of energy drinks, over-the-counter supplements, addiction or use of anhydrous caffeine products places individuals at risk for accidental overdose. An overdose of this drug is not without its attendant consequences on the liver and the Kidney. This study therefore aimed at evaluating the possible hepatoprotective and nephroprotective effects of <em>Citrullus vulgaris </em>seed extracts on caffeine induced toxicity. Thirty (30) male Wistar rats were divided into five groups. They were induced with caffeine (100 mg/kg) and treated with graded doses (100, 300 and 500 mg/ kg bwt.) of aqueous seeds extract of <em>C. vulgaris</em> for 21 days. The plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined and the concentrations of total protein, albumin, total bilirubin, creatinine and urea were estimated. Electrolytes (sodium, calcium, potassium and magnesium ion) were also estimated. Plasma lipid profiling (total cholesterol, triacylglyceride, high density lipoprotein (HDL), Low density lipoprotein (LDL) was carried out and the liver and kidney of the rats were examined for histopathological changes. The results showed that administration of aqueous seeds extract of <em>Citrullus vulgaris </em>restored the levels of the plasma enzymes, blood proteins, urea and creatinine as well as the levels of electrolytes close to normal control levels which were significantly altered by caffeine intoxication, Photomicrographs sections of the liver and kidney showed that the aqueous seeds extract of <em>Citrullus vulgaris</em> was able to repair damage to organs caused by caffeine-intoxication. The study concluded that the aqueous seeds extract of <em>C. vulgaris</em> possesses ameliorative potential against hepatic and renal damage that arises from caffeine-intoxication.</p>2024-01-10T00:00:00+00:00Copyright (c) 2024 Feyisayo et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://journalejmp.com/index.php/EJMP/article/view/1175Phytochemical Profile, Acute Toxicity, Antioxidant and Anti-inflammatory Activity of Hydroethanolic Extracts from Odontonema strictum (Nees) Kuntze (Acanthaceae) Root and Stem2024-02-16T13:10:02+00:00Nitiema Mathieunitmat01@yahoo.frBelemnaba Lazare Ouedraogo Windingoudi Rimwagna ChristianBelemlilga Bonewendé MohamedOuedraogo Salfo Koala Moumouni Traore AristideAhounou/Aïkpe Judith FifaminOuedraogo NoufouKini Bondo FélixOuedraogo Sylvin<p><strong>Background:</strong> The leaves of <em>Odontonema strictum</em> (Nees) Kuntze (Acanthaceae), a decorative plant native to Latin America, are used to treat hypertension in alternative medicine. However, the other parts of the plant have not yet been investigated for their antihypertensive properties. Aims: Our study aimed to investigate phytochemical groups with antihypertensive potential, antioxidant and anti-inflammatory properties, and the safety of using stems and roots hydroethanolic extracts.</p> <p><strong>Methodology:</strong> Phytochemical screening by HPTLC and determining flavonoids and total polyphenols were carried out. The antioxidant activity was evaluated using ABTS, FRAP, DPPH, and LPO methods. The inhibitory activity of Phospholipase A2 and 15-lipoxygenase was determined. Finally, acute oral toxicity was carried out on female mice NMRI.</p> <p><strong>Results:</strong> The hydroethanolic extracts of <em>Odontonema strictum</em> root (HE_ROS) and stem (HE_SOS) contain tannins, sterols, triterpenes, flavonoids, and saponosides. HE_SOS gave the highest levels of flavonoids (23.69±1.10 mg QE/g) and total phenolics (64.15±4.02 mg TAE/g. The two hydroethanolic extracts had antioxidant activity, with HE_ROS being the best. However, these activities were lower than Trolox (p<0.05). The extracts have a moderate inhibitory effect on 15-lipoxygenase and Phospholipase A2. Finally, HE_ROS and HE_SOS are practically non-toxic when administered once orally.</p> <p><strong>Conclusion:</strong> This study provided scientific data and could justify the use of <em>Odontonema strictum</em> in the treatment of hypertension.</p>2024-02-16T00:00:00+00:00Copyright (c) 2024 Mathieu et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://journalejmp.com/index.php/EJMP/article/view/1176A Comparative Study of the Antifungal Activity of Fresh and Dried Solanum anguivi Fruits on Candida albicans and Trichophyton rubrum2024-03-02T09:50:14+00:00Ouattara Sitapha sitaphao@yahoo.frKporou Kouassi Elisée Kra Adou Koffi MathieuAppia Franck Hermann DesireYapo Adou FrancisN’guessan Jean David Djaman Allico Joseph <p>In Côte d'Ivoire, as elsewhere in Africa, <em>Solanum anguivi</em> Lam is widely used in traditional medicine to treat bacterial and fungal infections. Given the importance of this plant, the extracts 70%, 80% and 100% from fresh and dried fruits was evaluated for the <em>in vitro</em> growth of two isolates of pathogenic fungi (<em>Candida albicans</em> and <em>Trichophyton rubrum</em>), as well as its anti-free radical activity. </p> <p>Antifungal tests were carried out by plating 1000 cells of each isolate on Sabouraud agar medium using the double dilution method in inclined tubes. Both extracts were active on the different strains tested, according to a dose-response relationship based on the principle of the method used.</p> <p>However, extracts from fresh fruit showed good activity on C. albicans, while the dried fresh fruit extracts were highly active on <em>T. rubrum. </em></p>2024-03-02T00:00:00+00:00Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.