Ethnomedicinal Study of Plants Used for Treatment of Diabetes, Hypertension and Cardiovascular Ailments in Fokoue and Santchou Subdivisions, Menoua Division of West Cameroon
European Journal of Medicinal Plants,
Page 12-30
DOI:
10.9734/ejmp/2022/v33i530464
Abstract
Background: In Cameroon, numerous people rely on medicinal plants and possess knowledge on the use of these plants. Plant knowledge from indigenous people is rapidly disappearing due to environmental, social and economic pressure, processes and changes. In view of this, ethnobotanical studies have been carried out in the area where medicinal plants are the main source of health care in order to preserve traditional knowledge of plant use. This study aims to document and quantify medicinal plant knowledge on the treatment of diabetes, hypertension and cardiovascular ailments in Fokoue and Santchou subdivisions of Menoua Division, West Cameroon.
Methods: Information related to medicinal plant species and plant remedies was collected through semi-structured interviews with 34 informants accompanied by homegarden sampling, walk-in-the-woods and snowball sampling. Quantitative methods were used to determine cultural importance index, relative frequency of citation and fidelity level which represent informants’ consensus.
Results: A total of 49 medicinal plant species representing 26 different botanical families were recorded in Fokoue and Santchou subdivisions of Menoua Division, West Cameroon. Most-cited plant families were Acanthaceae, Amaryllidaceae, Apocynaceae, Asteraceae, Lamiaceae, Poaceae and Rhamnaceae. Plant species Allium sativum, Aloe vera, Asystasia spp., Cymbopogon citratus, Gouania spp., Persea americana, Sonchus oleraceus and Vernonia amygdalina were considered as relatively important plants for treating diabetes, hypertension and cardiovascular ailments.
Conclusions: The study indicated the unique knowledge of medicinal plants used for treating diabetes, hypertension and cardiovascular ailments in Fokoue and Santchou subdivisions. Our findings not only confirm uses of medicinal plants documented elsewhere, but also add interesting new information that should be confirmed through formal biochemical analysis and clinical trials.
Keywords:
- Africa traditional medicine
- quantitative ethnobotany
- medicinal plants
How to Cite
Zhang, R., Verzelen, K., Tsobou, R., Vanhove, W., Nguetsop, V. F., & Damme, P. V. (2022). Ethnomedicinal Study of Plants Used for Treatment of Diabetes, Hypertension and Cardiovascular Ailments in Fokoue and Santchou Subdivisions, Menoua Division of West Cameroon. European Journal of Medicinal Plants, 33(5), 12-30. https://doi.org/10.9734/ejmp/2022/v33i530464
References
World Bank. World Development Indicators. Cause of death, by non-communicable diseases; 2012.
Available:http://data.worldbank.org/indicator/SH.DTH.NCOM.ZS. Accessed 04 Nov 2014.
WHO. Global status report on noncommunicable diseases 2010. Geneva: World Health Organization; 2011.
Busia K. Medical provision in Africa - past and present. Phytotherapy research. 2005;19(11):919-23.
DOI:10.1002/ptr.1775.
Cameron A, Ewen M, Ross-Degnan D, Ball D, Laing R. Medicine prices, availability, and affordability in 36 developing and middle-income countries: A secondary analysis. Lancet. 2009;373(9659):240-9.
DOI:10.1016/S0140-6736(08)61762-6.
Gurib-Fakim A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006;27 (1):1-93.
DOI:10.1016/j.mam.2005.07.008.
WHO. WHO traditional medicine strategy 2002-2005. Geneva: World Health Organization; 2002.
Mbeh GN, Edwards R, Ngufor G, Assah F, Fezeu L, Mbanya JC. Traditional healers and diabetes: Results from a pilot project to train traditional healers to provide health education and appropriate health care practices for diabetes patients in Cameroon. Global health promotion. 2010;17(2 Suppl):17-26.
DOI:10.1177/1757975910363925.
Mahomoodally MF. Traditional Medicines in Africa: An Appraisal of Ten Potent African Medicinal Plants. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:617459.
DOI:10.1155/2013/617459.
Ocvirk S, Kistler M, Khan S, Talukder SH, Hauner H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh--an ethnobotanical survey. Journal of Ethnobiology and Ethnomedicine. 2013; 9:43.
DOI:10.1186/1746-4269-9-43.
Keter LK, Mutiso PC. Ethnobotanical studies of medicinal plants used by Traditional Health Practitioners in the management of diabetes in Lower Eastern Province, Kenya. Journal of ethnopharmacology. 2012;139(1):74-80.
DOI:10.1016/j.jep.2011.10.014.
Aggarwal N, Shishu. A review of recent investigations on medicinal herbs possessing anti-diabetic properties. Journal of Nutrition Disorder Therapy. 2011;1(1):102. DOI:10.4172/jndt.1000102.
Chintamunnee V, Mahomoodally MF. Herbal medicine commonly used against non-communicable diseases in the tropical island of Mauritius. J Herb Med. 2012;2(4):113-25. DOI:10.1016/j.hermed.2012.06.001.
Kadir MF, Bin Sayeed MS, Shams T, Mia MM. Ethnobotanical survey of medicinal plants used by Bangladeshi traditional health practitioners in the management of diabetes mellitus. Journal of ethnopharmacology. 2012;144(3):605-11.
DOI:10.1016/j.jep.2012.09.050.
Semenya S, Potgieter M, Erasmus L. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa. Journal of ethnopharmacology. 2012;141(1):440-5.
DOI:10.1016/j.jep.2012.03.008.
Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology. 2004;92(1):1-21.
DOI:10.1016/j.jep.2003.12.031.
WHO. Noncommunicable diseases country profiles 2011. Geneva: World Health Organization; 2011.
Fokunang C, Ndikum V, Tabi O, Jiofack R, Ngameni B, Guedje N et al. Traditional Medicine: Past, present and future research and development prospects and integration in the National Health System of Cameroon. African Journal of Traditional, Complementary and Alternative Medicines. 2011;8(3):284-95.
Kuete V, Efferth T. Cameroonian medicinal plants: Pharmacology and derived natural products. Frontiers in pharmacology. 2010;1:123.
DOI:10.3389/fphar.2010.00123.
Institut National de la Statistique du Cameroun. Annuaire Statistique du Cameroun Institut National de la Statistique du Cameroun. 2011.
Available:http://www.stat.cm/. Accessed April 4 2014.
Cotton CM. Ethnobotany: Principles and applications. New York: Wiley; 1996.
Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnoveterinary plants of Ankober District, North Shewa Zone, Amhara Region, Ethiopia. Journal of ethnobiology and ethnomedicine. 2014;10(1):21.
DOI:10.1186/1746-4269-10-21.
Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnomedicinal study of plants used for human ailments in Ankober District, North Shewa Zone, Amhara region, Ethiopia. Journal of ethnobiology and ethnomedicine. 2013;9:63.
DOI:10.1186/1746-4269-9-63.
Thomas E, Vandebroek I, Van Damme P. What works in the field? A comparison of different interviewing methods in ethnobotany with special reference to the use of photographs. Economic Botany. 2007;61(4):376-84.
Martin GJ. Ethnobotany: A methods manual. London: Chapman & Hall; 1995.
International Plant Names Index [database on the Internet]2014.
Available: http://www.ipni.org. Accessed: 08 Apr. 2015
Missouri Botanical Garden [database on the Internet]. Available: http://www.tropicos.org. Accessed: 20 June 2014
Biernacki P, Waldorf D. Snowball Sampling - problems and techniques of chain referral sampling. Sociol Method Res. 1981;10(2):141-63.
Magnani R, Sabin K, Saidel T, Heckathorn D. Review of sampling hard-to-reach and hidden populations for HIV surveillance. Aids. 2005;19 Suppl 2:S67-72.
Tardio J, Pardo-De-Santayana M. Cultural importance indices: A comparative analysis based on the useful wild plants of southern Cantabria (northern Spain). Economic Botany. 2008;62(1):24-39. DOI:10.1007/s12231-007-9004-5.
Friedman J, Yaniv Z, Dafni A, Palewitch D. A preliminary classification of the healing potential of medicinal plants, based on a rational analysis of an ethnopharmacological field survey among Bedouins in the Negev desert, Israel. Journal of ethnopharmacology. 1986;16(2-3):275-87.
Makhubu L. Bioprospecting in an African context. Science. 1998;282(5386):41-2.
DOI:10.1126/science.282.5386.41.
Tabuti JRS, Kukunda CB, Kaweesi D, Kasilo OMJ. Herbal medicine use in the districts of Nakapiripirit, Pallisa, Kanungu, and Mukono in Uganda. Journal of ethnobiology and ethnomedicine. 2012;8:35.
DOI:10.1186/1746-4269-8-35.
Heinrich M, Edwards S, Moerman DE, Leonti M. Ethnopharmacological field studies: A critical assessment of their conceptual basis and methods. Journal of ethnopharmacology. 2009;124(1):1-17.
DOI:10.1016/j.jep.2009.03.043.
Sharma R, Manhas RK, Magotra R. Ethnoveterinary remedies of diseases among milk yielding animals in Kathua, Jammu and Kashmir, India. Journal of ethnopharmacology. 2012;141(1):265-72.
DOI:10.1016/j.jep.2012.02.027.
Thomas E, Semo L, Morales M, Noza Z, Nunez H, Cayuba A et al. Ethnomedicinal practices and medicinal plant knowledge of the Yuracares and Trinitarios from Indigenous Territory and National Park Isiboro-Secure, Bolivian Amazon. Journal of ethnopharmacology. 2011;133(1):153-63.
DOI:10.1016/j.jep.2010.09.017.
Thomas E, Vandebroek I, Sanca S, Van Damme P. Cultural significance of medicinal plant families and species among Quechua farmers in Apillapampa, Bolivia. Journal of ethnopharmacology. 2009;122(1):60-7.
DOI:10.1016/j.jep.2008.11.021.
Teklehaymanot T, Giday M. Quantitative ethnobotany of medicinal plants used by Kara and Kwego semi-pastoralist people in lower Omo River Valley, Debub Omo Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia. Journal of ethnopharmacology. 2010;130(1):76-84.
DOI:10.1016/j.jep.2010.04.013.
Din N, Dibong S, Mpondo EM, Priso R, Kwin N, Ngoye A. Inventory and identification of plants used in the treatment of diabetes in Douala town (Cameroon). European Journal of Medicinal Plants. 2011;1(3):60-73.
Tankou CM, de Snoo GR, de Iongh HH, Persoon G. Variation in plant biodiversity across sacred groves and fallows in Western Highlands of Cameroon. Afr J Ecol. 2014;52(1):10-9.
DOI:10.1111/aje.12079.
Thomas E, Van Damme P. Plant use and management in homegardens and swiddens: Evidence from the Bolivian Amazon. Agroforestry Systems. 2010;80(1):131-52.
DOI:10.1007/s10457-010-9315-x.
Gazzaneo LR, de Lucena RF, de Albuquerque UP. Knowledge and use of medicinal plants by local specialists in an region of Atlantic Forest in the state of Pernambuco (Northeastern Brazil). Journal of ethnobiology and ethnomedicine. 2005;1:9.
DOI:10.1186/1746-4269-1-9.
Alzweiri M, Al Sarhan A, Mansi K, Hudaib M, Aburjai T. Ethnopharmacological survey of medicinal herbs in Jordan, the Northern Badia region. Journal of ethnopharmacology. 2011;137(1):27-35.
DOI:10.1016/j.jep.2011.02.007.
Erharuyi O, Falodun A, Langer P. Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: A review. Asian Pac J Trop Med. 2014;7(1):1-8.
DOI:10.1016/S1995-7645(13)60182-0.
Jiofack T, Fokunang C, Guedje N, Kemeuze V, Fongnzossie E, Nkongmeneck BA et al. Ethnobotanical uses of some plants of two ethnoecological regions of Cameroon. Afr J Pharm Pharmaco. 2009;3(13):664-84.
Ntie-Kang F, Lifongo LL, Mbaze LM, Ekwelle N, Owono Owono LC, Megnassan E et al. Cameroonian medicinal plants: A bioactivity versus ethnobotanical survey and chemotaxonomic classification. BMC complementary and alternative medicine. 2013;13:147. DOI:10.1186/1472-6882-13-147.
Nyunaï N, Manguelle-Dicoum A, Njifutié N, Abdennebi E, Gerard C. Antihyperglycaemic effect of Ageratum conyzoides L. fractions in normoglycemic and diabetic male wistar rats. International Journal of Biomedical and Pharmaceutical Sciences. 2010;4(1):38-42.
Nasrin F. Antioxidant and cytotoxic activities of Ageratum conyzoides stems. International Current Pharmaceutical Journal. 2013;2(2):33-7.
DOI:10.3329/icpj.v2i2.13195.
Agunbiade OS, Ojezele OM, Ojezele JO, Ajayi AY. Hypoglycaemic activity of Commelina africana and Ageratum conyzoides in relation to their mineral composition. African health sciences. 2012;12(2):198-203.
DOI:10.4314/ahs.v12i2.19.
Upadhyay B, Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. Journal of ethnopharmacology. 2010;129(1):64-86.
DOI:10.1016/j.jep.2010.02.026.
Gronhaug TE, Glaeserud S, Skogsrud M, Ballo N, Bah S, Diallo D et al. Ethnopharmacological survey of six medicinal plants from Mali, West-Africa. Journal of ethnobiology and ethnomedicine. 2008;4:26.
DOI:10.1186/1746-4269-4-26.
Nanyingi MO, Mbaria JM, Lanyasunya AL, Wagate CG, Koros KB, Kaburia HF et al. Ethnopharmacological survey of Samburu district, Kenya. Journal of ethnobiology and ethnomedicine. 2008;4:14.
DOI:10.1186/1746-4269-4-14.
Tabuti JRS, Dhillion SS, Lye KA. Traditional medicine in Bulamogi county, Uganda: its practitioners, users and viability. Journal of ethnopharmacology. 2003;85(1):119-29.
DOI:10.1016/S0378-8741(02)00378-1.
Calapai G, Caputi AP. Herbal medicines: Can we do without pharmacologist? Evidence-Based Complementary and Alternative Medicine. 2007;4(Suppl 1):41-3.
Panyaphu K, On TV, Sirisa-ard P, Srisa-nga P, ChansaKaow S, Nathakarnkitkul S. Medicinal plants of the Mien (Yao) in Northern Thailand and their potential value in the primary healthcare of postpartum women. Journal of ethnopharmacology. 2011;135(2):226-37.
DOI:10.1016/j.jep.2011.03.050.
Gachet MS, Lecaro JS, Kaiser M, Brun R, Navarrete H, Munoz RA et al. Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology. 2010;128(1):184-97.
DOI:10.1016/j.jep.2010.01.007.
Ezeja MI, Anaga AO, Asuzu IU. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats. Journal of Ethnopharmacology. 2014;151(3):1155-64.
DOI:10.1016/j.jep.2013.12.034.
Giacomelli SR, Maldaner G, Stucker C, Marasciulo C, Schmidt J, Wessjohann L et al. Triterpenoids from Gouania ulmifolia. Planta medica. 2007;73(5):499-501.
DOI:10.1055/s-2007-967166.
Buerki S, Phillipson PB, Callmander MW. A taxonomic revision of Gouania (Rhamnaceae) in Madagascar and the other islands of the Western Indian Ocean (the Comoro and Mascarene Islands, and the Seychelles). Missouri Botanical Garden. 2011;98(2):157-95.
DOI:10.3417/2007075.
Lima CR, Vasconcelos CFB, Costa-Silva JH, Maranhao CA, Costa J, Batista TM et al. Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. Journal of ethnopharmacology. 2012;141(1):517-25.
DOI:10.1016/j.jep.2012.03.026.
Ojewole JA, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT. Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals. Cardiovascular journal of Africa. 2007;18(2):69-76.
Yun H-M, Ban JO, Park K-R, Lee CK, Jeong H-S, Han SB et al. Potential therapeutic effects of functionally active compounds isolated from garlic. Pharmacology & Therapeutics. 2014;142(2):183-95.
DOI:10.1016/j.pharmthera.2013.12.005.
Noumi E, Houngue F, Lontsi D. Traditional medicines in primary health care: Plants used for the treatment of hypertension in Bafia, Cameroon. Fitoterapia. 1999;70(2):134-9.
DOI:10.1016/S0367-326x(98)00025-2.
Teugwa CM, Mejiato PC, Zofou D, Tchinda BT, Boyom FF. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC complementary and alternative medicine. 2013;13:175.
DOI:10.1186/1472-6882-13-175.
AbouZid SF, Ahmed OM, Ahmed RR, Mahmoud A, Abdella E, Ashour MB. Antihyperglycemic effect of crude extracts of some Egyptian plants and algae. Journal of medicinal food. 2014;17(3):400-6.
DOI:10.1089/jmf.2013.0068.
Ahmed O, Hozayen W, Bastawy M, Hamed M. Biochemical effects of Cichorium intybus and Sonchus oleraceus infusions and esculetin on streptozotocin-induced diabetic albino rats. Journal of American Science. 2011;7(12):1124-37.
Campos J, Schmeda-Hirschmann G, Leiva E, Guzman L, Orrego R, Fernandez P et al. Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chemistry. 2014; 151:175-81.
DOI:10.1016/j.foodchem.2013.11.018.
Gayathri K, Jayachandran KS, Vasanthi HR, Rajamanickam GV. Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity. Hum Exp Toxicol. 2011;30(8):1073-82.
DOI:10.1177/0960327110386391.
Ghorbani A, Langenberger G, Feng L, Sauerborn J. Ethnobotanical study of medicinal plants utilised by Hani ethnicity in Naban River Watershed National Nature Reserve, Yunnan, China. Journal of ethnopharmacology. 2011;134(3):651-67.
DOI:10.1016/j.jep.2011.01.011.
Lanzotti V. The analysis of onion and garlic. J Chromatogr A. 2006;1112(1-2):3-22. DOI:10.1016/j.chroma.2005.12.016.
Kook S, Kim GH, Choi K. The antidiabetic effect of onion and garlic in experimental diabetic rats: Meta-analysis. Journal of medicinal food. 2009;12(3):552-60.
DOI:10.1089/jmf.2008.1071.
Camou-Guerrero A, Reyes-Garcia V, Martinez-Ramos M, Casas A. Knowledge and use value of plant species in a Raramuri community: A gender perspective for conservation. Hum Ecol. 2008;36(2):259-72.
DOI:10.1007/s10745-007-9152-3.
Vogler BK, Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Brit J Gen Pract. 1999;49(447):823-8.
Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Planta medica. 2012;78(4):311-6.
DOI:10.1055/s-003-1280474.
Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: Randomized controlled trial. Nutrition. 2013;29(9):1110-4.
DOI:10.1016/j.nut.2013.02.015.
Atangwho IJ, Edet EE, Uti DE, Obi AU, Asmawi MZ, Ahmad M. Biochemical and histological impact of Vernonia amygdalina supplemented diet in obese rats. Saudi J Biol Sci. 2012;19(3):385-92.
DOI:10.1016/j.sjbs.2012.05.003.
Atangwho IJ, Egbung GE, Ahmad M, Yam MF, Asmawi MZ. Antioxidant versus anti-diabetic properties of leaves from Vernonia amygdalina Del. growing in Malaysia. Food chemistry. 2013;141(4):3428-34.
DOI:10.1016/j.foodchem.2013.06.047.
Mugabo P, Raji IA. Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. BMC complementary and alternative medicine. 2013;13:283.
DOI:10.1186/1472-6882-13-283.
Rotimi SO, Omotosho OE, Rotimi OA. Persistence of acidosis in alloxan-induced diabetic rats treated with the juice of Asystasia gangetica leaves. Pharmacognosy magazine. 2011;7(25):25-30.
DOI:10.4103/0973-1296.75887.
Available:http://data.worldbank.org/indicator/SH.DTH.NCOM.ZS. Accessed 04 Nov 2014.
WHO. Global status report on noncommunicable diseases 2010. Geneva: World Health Organization; 2011.
Busia K. Medical provision in Africa - past and present. Phytotherapy research. 2005;19(11):919-23.
DOI:10.1002/ptr.1775.
Cameron A, Ewen M, Ross-Degnan D, Ball D, Laing R. Medicine prices, availability, and affordability in 36 developing and middle-income countries: A secondary analysis. Lancet. 2009;373(9659):240-9.
DOI:10.1016/S0140-6736(08)61762-6.
Gurib-Fakim A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006;27 (1):1-93.
DOI:10.1016/j.mam.2005.07.008.
WHO. WHO traditional medicine strategy 2002-2005. Geneva: World Health Organization; 2002.
Mbeh GN, Edwards R, Ngufor G, Assah F, Fezeu L, Mbanya JC. Traditional healers and diabetes: Results from a pilot project to train traditional healers to provide health education and appropriate health care practices for diabetes patients in Cameroon. Global health promotion. 2010;17(2 Suppl):17-26.
DOI:10.1177/1757975910363925.
Mahomoodally MF. Traditional Medicines in Africa: An Appraisal of Ten Potent African Medicinal Plants. Evidence-based complementary and alternative medicine : eCAM. 2013;2013:617459.
DOI:10.1155/2013/617459.
Ocvirk S, Kistler M, Khan S, Talukder SH, Hauner H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh--an ethnobotanical survey. Journal of Ethnobiology and Ethnomedicine. 2013; 9:43.
DOI:10.1186/1746-4269-9-43.
Keter LK, Mutiso PC. Ethnobotanical studies of medicinal plants used by Traditional Health Practitioners in the management of diabetes in Lower Eastern Province, Kenya. Journal of ethnopharmacology. 2012;139(1):74-80.
DOI:10.1016/j.jep.2011.10.014.
Aggarwal N, Shishu. A review of recent investigations on medicinal herbs possessing anti-diabetic properties. Journal of Nutrition Disorder Therapy. 2011;1(1):102. DOI:10.4172/jndt.1000102.
Chintamunnee V, Mahomoodally MF. Herbal medicine commonly used against non-communicable diseases in the tropical island of Mauritius. J Herb Med. 2012;2(4):113-25. DOI:10.1016/j.hermed.2012.06.001.
Kadir MF, Bin Sayeed MS, Shams T, Mia MM. Ethnobotanical survey of medicinal plants used by Bangladeshi traditional health practitioners in the management of diabetes mellitus. Journal of ethnopharmacology. 2012;144(3):605-11.
DOI:10.1016/j.jep.2012.09.050.
Semenya S, Potgieter M, Erasmus L. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa. Journal of ethnopharmacology. 2012;141(1):440-5.
DOI:10.1016/j.jep.2012.03.008.
Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology. 2004;92(1):1-21.
DOI:10.1016/j.jep.2003.12.031.
WHO. Noncommunicable diseases country profiles 2011. Geneva: World Health Organization; 2011.
Fokunang C, Ndikum V, Tabi O, Jiofack R, Ngameni B, Guedje N et al. Traditional Medicine: Past, present and future research and development prospects and integration in the National Health System of Cameroon. African Journal of Traditional, Complementary and Alternative Medicines. 2011;8(3):284-95.
Kuete V, Efferth T. Cameroonian medicinal plants: Pharmacology and derived natural products. Frontiers in pharmacology. 2010;1:123.
DOI:10.3389/fphar.2010.00123.
Institut National de la Statistique du Cameroun. Annuaire Statistique du Cameroun Institut National de la Statistique du Cameroun. 2011.
Available:http://www.stat.cm/. Accessed April 4 2014.
Cotton CM. Ethnobotany: Principles and applications. New York: Wiley; 1996.
Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnoveterinary plants of Ankober District, North Shewa Zone, Amhara Region, Ethiopia. Journal of ethnobiology and ethnomedicine. 2014;10(1):21.
DOI:10.1186/1746-4269-10-21.
Lulekal E, Asfaw Z, Kelbessa E, Van Damme P. Ethnomedicinal study of plants used for human ailments in Ankober District, North Shewa Zone, Amhara region, Ethiopia. Journal of ethnobiology and ethnomedicine. 2013;9:63.
DOI:10.1186/1746-4269-9-63.
Thomas E, Vandebroek I, Van Damme P. What works in the field? A comparison of different interviewing methods in ethnobotany with special reference to the use of photographs. Economic Botany. 2007;61(4):376-84.
Martin GJ. Ethnobotany: A methods manual. London: Chapman & Hall; 1995.
International Plant Names Index [database on the Internet]2014.
Available: http://www.ipni.org. Accessed: 08 Apr. 2015
Missouri Botanical Garden [database on the Internet]. Available: http://www.tropicos.org. Accessed: 20 June 2014
Biernacki P, Waldorf D. Snowball Sampling - problems and techniques of chain referral sampling. Sociol Method Res. 1981;10(2):141-63.
Magnani R, Sabin K, Saidel T, Heckathorn D. Review of sampling hard-to-reach and hidden populations for HIV surveillance. Aids. 2005;19 Suppl 2:S67-72.
Tardio J, Pardo-De-Santayana M. Cultural importance indices: A comparative analysis based on the useful wild plants of southern Cantabria (northern Spain). Economic Botany. 2008;62(1):24-39. DOI:10.1007/s12231-007-9004-5.
Friedman J, Yaniv Z, Dafni A, Palewitch D. A preliminary classification of the healing potential of medicinal plants, based on a rational analysis of an ethnopharmacological field survey among Bedouins in the Negev desert, Israel. Journal of ethnopharmacology. 1986;16(2-3):275-87.
Makhubu L. Bioprospecting in an African context. Science. 1998;282(5386):41-2.
DOI:10.1126/science.282.5386.41.
Tabuti JRS, Kukunda CB, Kaweesi D, Kasilo OMJ. Herbal medicine use in the districts of Nakapiripirit, Pallisa, Kanungu, and Mukono in Uganda. Journal of ethnobiology and ethnomedicine. 2012;8:35.
DOI:10.1186/1746-4269-8-35.
Heinrich M, Edwards S, Moerman DE, Leonti M. Ethnopharmacological field studies: A critical assessment of their conceptual basis and methods. Journal of ethnopharmacology. 2009;124(1):1-17.
DOI:10.1016/j.jep.2009.03.043.
Sharma R, Manhas RK, Magotra R. Ethnoveterinary remedies of diseases among milk yielding animals in Kathua, Jammu and Kashmir, India. Journal of ethnopharmacology. 2012;141(1):265-72.
DOI:10.1016/j.jep.2012.02.027.
Thomas E, Semo L, Morales M, Noza Z, Nunez H, Cayuba A et al. Ethnomedicinal practices and medicinal plant knowledge of the Yuracares and Trinitarios from Indigenous Territory and National Park Isiboro-Secure, Bolivian Amazon. Journal of ethnopharmacology. 2011;133(1):153-63.
DOI:10.1016/j.jep.2010.09.017.
Thomas E, Vandebroek I, Sanca S, Van Damme P. Cultural significance of medicinal plant families and species among Quechua farmers in Apillapampa, Bolivia. Journal of ethnopharmacology. 2009;122(1):60-7.
DOI:10.1016/j.jep.2008.11.021.
Teklehaymanot T, Giday M. Quantitative ethnobotany of medicinal plants used by Kara and Kwego semi-pastoralist people in lower Omo River Valley, Debub Omo Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia. Journal of ethnopharmacology. 2010;130(1):76-84.
DOI:10.1016/j.jep.2010.04.013.
Din N, Dibong S, Mpondo EM, Priso R, Kwin N, Ngoye A. Inventory and identification of plants used in the treatment of diabetes in Douala town (Cameroon). European Journal of Medicinal Plants. 2011;1(3):60-73.
Tankou CM, de Snoo GR, de Iongh HH, Persoon G. Variation in plant biodiversity across sacred groves and fallows in Western Highlands of Cameroon. Afr J Ecol. 2014;52(1):10-9.
DOI:10.1111/aje.12079.
Thomas E, Van Damme P. Plant use and management in homegardens and swiddens: Evidence from the Bolivian Amazon. Agroforestry Systems. 2010;80(1):131-52.
DOI:10.1007/s10457-010-9315-x.
Gazzaneo LR, de Lucena RF, de Albuquerque UP. Knowledge and use of medicinal plants by local specialists in an region of Atlantic Forest in the state of Pernambuco (Northeastern Brazil). Journal of ethnobiology and ethnomedicine. 2005;1:9.
DOI:10.1186/1746-4269-1-9.
Alzweiri M, Al Sarhan A, Mansi K, Hudaib M, Aburjai T. Ethnopharmacological survey of medicinal herbs in Jordan, the Northern Badia region. Journal of ethnopharmacology. 2011;137(1):27-35.
DOI:10.1016/j.jep.2011.02.007.
Erharuyi O, Falodun A, Langer P. Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: A review. Asian Pac J Trop Med. 2014;7(1):1-8.
DOI:10.1016/S1995-7645(13)60182-0.
Jiofack T, Fokunang C, Guedje N, Kemeuze V, Fongnzossie E, Nkongmeneck BA et al. Ethnobotanical uses of some plants of two ethnoecological regions of Cameroon. Afr J Pharm Pharmaco. 2009;3(13):664-84.
Ntie-Kang F, Lifongo LL, Mbaze LM, Ekwelle N, Owono Owono LC, Megnassan E et al. Cameroonian medicinal plants: A bioactivity versus ethnobotanical survey and chemotaxonomic classification. BMC complementary and alternative medicine. 2013;13:147. DOI:10.1186/1472-6882-13-147.
Nyunaï N, Manguelle-Dicoum A, Njifutié N, Abdennebi E, Gerard C. Antihyperglycaemic effect of Ageratum conyzoides L. fractions in normoglycemic and diabetic male wistar rats. International Journal of Biomedical and Pharmaceutical Sciences. 2010;4(1):38-42.
Nasrin F. Antioxidant and cytotoxic activities of Ageratum conyzoides stems. International Current Pharmaceutical Journal. 2013;2(2):33-7.
DOI:10.3329/icpj.v2i2.13195.
Agunbiade OS, Ojezele OM, Ojezele JO, Ajayi AY. Hypoglycaemic activity of Commelina africana and Ageratum conyzoides in relation to their mineral composition. African health sciences. 2012;12(2):198-203.
DOI:10.4314/ahs.v12i2.19.
Upadhyay B, Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. Journal of ethnopharmacology. 2010;129(1):64-86.
DOI:10.1016/j.jep.2010.02.026.
Gronhaug TE, Glaeserud S, Skogsrud M, Ballo N, Bah S, Diallo D et al. Ethnopharmacological survey of six medicinal plants from Mali, West-Africa. Journal of ethnobiology and ethnomedicine. 2008;4:26.
DOI:10.1186/1746-4269-4-26.
Nanyingi MO, Mbaria JM, Lanyasunya AL, Wagate CG, Koros KB, Kaburia HF et al. Ethnopharmacological survey of Samburu district, Kenya. Journal of ethnobiology and ethnomedicine. 2008;4:14.
DOI:10.1186/1746-4269-4-14.
Tabuti JRS, Dhillion SS, Lye KA. Traditional medicine in Bulamogi county, Uganda: its practitioners, users and viability. Journal of ethnopharmacology. 2003;85(1):119-29.
DOI:10.1016/S0378-8741(02)00378-1.
Calapai G, Caputi AP. Herbal medicines: Can we do without pharmacologist? Evidence-Based Complementary and Alternative Medicine. 2007;4(Suppl 1):41-3.
Panyaphu K, On TV, Sirisa-ard P, Srisa-nga P, ChansaKaow S, Nathakarnkitkul S. Medicinal plants of the Mien (Yao) in Northern Thailand and their potential value in the primary healthcare of postpartum women. Journal of ethnopharmacology. 2011;135(2):226-37.
DOI:10.1016/j.jep.2011.03.050.
Gachet MS, Lecaro JS, Kaiser M, Brun R, Navarrete H, Munoz RA et al. Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology. 2010;128(1):184-97.
DOI:10.1016/j.jep.2010.01.007.
Ezeja MI, Anaga AO, Asuzu IU. Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats. Journal of Ethnopharmacology. 2014;151(3):1155-64.
DOI:10.1016/j.jep.2013.12.034.
Giacomelli SR, Maldaner G, Stucker C, Marasciulo C, Schmidt J, Wessjohann L et al. Triterpenoids from Gouania ulmifolia. Planta medica. 2007;73(5):499-501.
DOI:10.1055/s-2007-967166.
Buerki S, Phillipson PB, Callmander MW. A taxonomic revision of Gouania (Rhamnaceae) in Madagascar and the other islands of the Western Indian Ocean (the Comoro and Mascarene Islands, and the Seychelles). Missouri Botanical Garden. 2011;98(2):157-95.
DOI:10.3417/2007075.
Lima CR, Vasconcelos CFB, Costa-Silva JH, Maranhao CA, Costa J, Batista TM et al. Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats. Journal of ethnopharmacology. 2012;141(1):517-25.
DOI:10.1016/j.jep.2012.03.026.
Ojewole JA, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT. Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals. Cardiovascular journal of Africa. 2007;18(2):69-76.
Yun H-M, Ban JO, Park K-R, Lee CK, Jeong H-S, Han SB et al. Potential therapeutic effects of functionally active compounds isolated from garlic. Pharmacology & Therapeutics. 2014;142(2):183-95.
DOI:10.1016/j.pharmthera.2013.12.005.
Noumi E, Houngue F, Lontsi D. Traditional medicines in primary health care: Plants used for the treatment of hypertension in Bafia, Cameroon. Fitoterapia. 1999;70(2):134-9.
DOI:10.1016/S0367-326x(98)00025-2.
Teugwa CM, Mejiato PC, Zofou D, Tchinda BT, Boyom FF. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae). BMC complementary and alternative medicine. 2013;13:175.
DOI:10.1186/1472-6882-13-175.
AbouZid SF, Ahmed OM, Ahmed RR, Mahmoud A, Abdella E, Ashour MB. Antihyperglycemic effect of crude extracts of some Egyptian plants and algae. Journal of medicinal food. 2014;17(3):400-6.
DOI:10.1089/jmf.2013.0068.
Ahmed O, Hozayen W, Bastawy M, Hamed M. Biochemical effects of Cichorium intybus and Sonchus oleraceus infusions and esculetin on streptozotocin-induced diabetic albino rats. Journal of American Science. 2011;7(12):1124-37.
Campos J, Schmeda-Hirschmann G, Leiva E, Guzman L, Orrego R, Fernandez P et al. Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chemistry. 2014; 151:175-81.
DOI:10.1016/j.foodchem.2013.11.018.
Gayathri K, Jayachandran KS, Vasanthi HR, Rajamanickam GV. Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity. Hum Exp Toxicol. 2011;30(8):1073-82.
DOI:10.1177/0960327110386391.
Ghorbani A, Langenberger G, Feng L, Sauerborn J. Ethnobotanical study of medicinal plants utilised by Hani ethnicity in Naban River Watershed National Nature Reserve, Yunnan, China. Journal of ethnopharmacology. 2011;134(3):651-67.
DOI:10.1016/j.jep.2011.01.011.
Lanzotti V. The analysis of onion and garlic. J Chromatogr A. 2006;1112(1-2):3-22. DOI:10.1016/j.chroma.2005.12.016.
Kook S, Kim GH, Choi K. The antidiabetic effect of onion and garlic in experimental diabetic rats: Meta-analysis. Journal of medicinal food. 2009;12(3):552-60.
DOI:10.1089/jmf.2008.1071.
Camou-Guerrero A, Reyes-Garcia V, Martinez-Ramos M, Casas A. Knowledge and use value of plant species in a Raramuri community: A gender perspective for conservation. Hum Ecol. 2008;36(2):259-72.
DOI:10.1007/s10745-007-9152-3.
Vogler BK, Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Brit J Gen Pract. 1999;49(447):823-8.
Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Planta medica. 2012;78(4):311-6.
DOI:10.1055/s-003-1280474.
Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: Randomized controlled trial. Nutrition. 2013;29(9):1110-4.
DOI:10.1016/j.nut.2013.02.015.
Atangwho IJ, Edet EE, Uti DE, Obi AU, Asmawi MZ, Ahmad M. Biochemical and histological impact of Vernonia amygdalina supplemented diet in obese rats. Saudi J Biol Sci. 2012;19(3):385-92.
DOI:10.1016/j.sjbs.2012.05.003.
Atangwho IJ, Egbung GE, Ahmad M, Yam MF, Asmawi MZ. Antioxidant versus anti-diabetic properties of leaves from Vernonia amygdalina Del. growing in Malaysia. Food chemistry. 2013;141(4):3428-34.
DOI:10.1016/j.foodchem.2013.06.047.
Mugabo P, Raji IA. Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. BMC complementary and alternative medicine. 2013;13:283.
DOI:10.1186/1472-6882-13-283.
Rotimi SO, Omotosho OE, Rotimi OA. Persistence of acidosis in alloxan-induced diabetic rats treated with the juice of Asystasia gangetica leaves. Pharmacognosy magazine. 2011;7(25):25-30.
DOI:10.4103/0973-1296.75887.
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