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Chemical Constituents from Wood of Zanthoxylum rigidum Hum. & Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activity

  • Carlos H. C. dos Santos
  • Mayara C. Sousa
  • Paulo T. de Sousa Jr.
  • Tereza A. N. Ribeiro
  • Marco J. Jacinto
  • Virgínia C. Paulino Silva

European Journal of Medicinal Plants, Page 14-20
DOI: 10.9734/ejmp/2021/v32i530390
Published: 15 July 2021

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Abstract


In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).


Keywords:
  • Zanthoxylum rigidum
  • antileishmanial
  • Leishmania braziliensis
  • Leishmania chagasi
  • NMR
  • MS
  • Full Article – PDF
  • Review History

How to Cite

Santos, C. H. C. dos, Sousa, M. C., Jr., P. T. de S., Ribeiro, T. A. N., Jacinto, M. J., & Silva, V. C. P. (2021). Chemical Constituents from Wood of Zanthoxylum rigidum Hum. & Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activity. European Journal of Medicinal Plants, 32(5), 14-20. https://doi.org/10.9734/ejmp/2021/v32i530390
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