Chemical Constituents from Wood of Zanthoxylum rigidum Hum. & Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activity
European Journal of Medicinal Plants,
Page 14-20
DOI:
10.9734/ejmp/2021/v32i530390
Abstract
In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).
Keywords:
- Zanthoxylum rigidum
- antileishmanial
- Leishmania braziliensis
- Leishmania chagasi
- NMR
- MS
How to Cite
References
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