A Review on Herbal Remedies for Sexually Transmitted Infections (STIs) from Melghat Region of Maharashtra State, India

Main Article Content

Nitin M. Atre
Dinesh D. Khedkar

Abstract

Melghat means "meeting of ghats" region well known for "Melghat Tiger Reserve (MTR)" located in the north-western compact block of Amravati district in Maharashtra state, India. This literature review aimed to compile and document the herbal remedies for Sexually Transmitted Infections (STIs) as Gonorrhoea, anti-HIV Leucorrhoea, Sexual Transmitted Diseases (STDs), and Syphilis in Melghat region. A total of 167 medicinal plant species from Melghat distributed among 137 genera, and 66 families have complied for Gonorrhea (103), Syphilis (85), Leucorrhoea (84), anti-HIV (10), and STD (01). Plant families like Lythraceae (17 species), Malvaceae (11 species), Moraceae (8 species), Euphorbiaceae (8 species), Acanthaceae (6 species), Amaranthaceae (6 species), Verbenaceae (6 species), were most frequently occurred in the study. Trees represented 34.13% of species, followed by Herbs (32.33%), Shrubs (20.95%), Climbers (10.17%), Grasses (1.19%), Orchids (0.59%) and Aquatic (0.59%). Leaves were the most commonly used plant parts; it accounts 19% followed by roots (18%), whole plant (13%), bark (13%), seeds (7%), fruits (6%), stem (5%), flowers (5%), etc. Curated data presented as botanical names, families, local names, habitat, floristic area (in Melghat), ailments, part used with relevant ethnobotanical citations were documented and thus offers scope for researchers engaged in herbal drug discovery and development.

Keywords:
Medicinal plants, Melghat Flora, Gonorrhoea, Leucorrhoeaq, Syphilis, HIV, STIs.

Article Details

How to Cite
Atre, N. M., & Khedkar, D. D. (2020). A Review on Herbal Remedies for Sexually Transmitted Infections (STIs) from Melghat Region of Maharashtra State, India. European Journal of Medicinal Plants, 31(14), 1-17. https://doi.org/10.9734/ejmp/2020/v31i1430313
Section
Review Article

References

Birdi TJ, Joshi S, Kotian S, Shah S. Possible Causes of Malnutrition in Melghat, a Tribal Region of Maharashtra, India. Global Journal of Health Science. 2014;6(5):164–173.

Patel RI. Forest Flora of Melghat. Prabhat Press Meerut; 1968.

Dhore MA, Joshi PA. Flora of Melghat Tiger Reserve. Directorate, Project Tiger, Melghat; 1988.

Bhogaonkar PY, Devarkar VD. Additions to the Flora of Melghat (some rare and uncommon plants). The Directorate Project Tiger, Melghat. Technical Bulletin No. VII; 1998.

Bhogaonkar P, Devarkar V. Studies in Ethnobotany of Melghat (Amravati Dist. Amravati) I Antisterility Drugs. BRI'S JAST. 2001;4 (I and II):63-66.

Devarkar V. Ethnobotanical Studies of Korkus of Melghat (Distt.Amravati) with special reference to ethnomedicine [dissertation]. Amravati: Sant Gadge Baba Amravati University, Amravati; 2001.

Londhe AN, Watve AV, Ansari MY. Additions to the flora of Melghat Tiger Reserve. J Econ Taxon Bot. 2002;26(2):385-395.

Bhogaonkar P, Devarkar V. Some unique ethnomedicinal plants of Korkus of Melghat Tiger Reserve (Maharashtra). Ethnobotany. 2002;14:16-19.

Sakarkar D, Sakarkar U, Sakarkar N, Shrikhande V, Vyas V, Kale R. Medicinal plants used by the tribals for hair disorders in Melghat forest of Amravati district, Maharashtra. Nat Prod Radiance. 2004;3(5):351-355.

Shirsat RP. Ethnomedicinal Uses of Some Common Lower Plants Used by Tribals of Melghat Region ( MS ) India Material and Methods : Ethnobot Leafl. 2008;12:667-669.

Bhogaonkar P, Marathe V, Kshirsagar P. Documentation of Wild Edible Plants of Melghat Forest, Dist. Amaravti, Maharashtra State, India. Ethnobot Leafl. 2010;14(7):51-58.

Yeotkar S, Malode S, Jadhao K. Investigation of minerals from saome ethano-medicinal and medicinal plants from melghat region. BIONANO Front. 2010;3(2):268-272.

Devarkar VD. Plants of great medicinal value from Korku ethnomedicne. Bioscience Discovery 2010;1(1):21–25.

Rothe SP, Muratkar GD, Kokate UR. Occurrence and diversity in host by Mistletoes from fire families in East Melghat. Curr Bot. 2011;2(9):19-21.

Ingole S. Diversity and useful products in some Verbenaceous member of Melghat and Amravati regions, Maharashtra, India. Biodiversitas, J Biol Divers. 2011;12(3):146-163. DOI:10.13057/biodiv/d120305

Kokate UR, Muratkar GD. Diversity of Medicinal plants from Melghat forests. Multilogic Sci. 2012;2(2):61-67

Zade V, Dhore M, Dabhadkar D, Pare S, Wikhe M, Deshmukh V, Chede S. Indigenous Herbal Remedies Used by Tribals of Melghat Region of Amravati District for Regulation of Antifertility and Aphrodisiac Activity. Int J Res Pharm Biomed Sci. 2013;4(4):1104-1109.

Khedkar DD and Oke AV. Phytochemical profiling of crude extracts from Radermachera xylocarpa (Roxb.) K. Schum. Int J Pharma Bio Sci. 2013;4(2):867-871.

Talapalliwar MR, Garg BS. Nutritional Status and its Correlates Among Tribal Children of Melghat, Central India. Indian Journal of Pediatrics. 2014;81:1151-1157. DOI.org/10.1007/s12098-014-1358-y

Kashyap RS, Nayak AR, Husain AA, Shekhawat SD, Satav AR, Jain RK, Raje DV, Daginawala HF, Taori GM. Impact of socioeconomic status and living condition on latent tuberculosis diagnosis among the tribal population of Melghat: A cohort study. Lung India. 2016;33(4):372-380. DOI:10.4103/0970-2113.184868

Bhogaonkar P, Dhole P. Checklist of Flora of Melghat. Amravati: Chief Conservator of Forest & Field Director, Melghat Tiger Project, Amravati; 2018-19.

Khedkar DD, Atre NM. Medicinal Flora of Melghat for Asthma – A Review. J Pharmacogn Phytochem. 2019;8(2):2091-2095.

Judson F. Sexually Transmitted Infections. 1st ed. (Kumar B, Gupta S, eds.). Elsevier: New Delhi; 2005.

Ng LK, Martin IE. The laboratory diagnosis of Neisseria Gonorrheae. Can J Infect Dis Med Microbiol. 2005;16(1):15-25. DOI:10.1155/2005/323082

Zielke RA, Wierzbicki IH, Baarda BI, Sikora AE. The Neisseria Gonorrheae Obg protein is an essential ribosome-associated GTPase and a potential drug target. BMC Microbiol. 2015;15(1):1-14. DOI:10.1186/s12866-015-0453-1

Thappa D and Kaimal S. Sexually Transmitted Infections In India : Current Status (Except Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome). Indian J Dermatol. 2007;52(2):78–82. DOI:10.4103/0019-5154.33283

Rowley J, Hoorn SV, Korenromp E, Low N, Unemo M, Laith J, Chico RM, Smolak A, Newman L, Gottlieb S, Thwin S, Broutet N, Taylor MM. Chlamydia, Gonorrhea, Trichomoniasis and Syphilis: Global Prevalence and Incidence Estimates. Bulletin of the World Health Organization. 2016;1-43.

Das DC, Sinha NK, Chattopadhyay JC, Das M and Samanta P. The use of medicinal plant for the treatment of Gonorrhea and Syphilis in South West Bengal of India. International Journal of Phytomedicine. 2013;5(1):14-17.

Pandey MM, Rastogi S, Rawat AKS. Indian traditional ayurvedic system of medicine and nutritional supplementation. Evidence-based Complement Altern Med; 2013. DOI:10.1155/2013/376327

Yadav JP, Kumar S, Siwach P. Folk medicine used in gynecological and other related problems by rural population of Haryana. Indian Journal of Traditional Knowledge. 2006;5(3):323-326

Malviya S, Rawat S, Kharia A, Verma M. Medicinal attributes of Acacia nilotica Linn. - A comprehensive review on ethnopharmacological claims. Int. J. of Pharm. & Life Sci. 2011;2(6):830-837.

Shankar R, Tripathi AK, Anku G, Neyaz S, Rawat MS. Indigenous medicinal plants of Northeast India in Human health: Leterary Note. J Drug Res Ayurvedic Sci. 2017;2(2):104-117.

Tripathi R, Dwivedi SN, Dwivedi S. Ethno-medicinal plants used to treat gynecological disorders by tribal people of Madhya Pradesh, India. IJPLS. 2010;1(3):160-169.

Mali PY, Panchal SS. Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities. Asian Pacific Journal of Tropical Medicine. 2017;10(5):430–438.

Bitasta M, Madan S. Aerva lanata: A blessing of Mother Nature. Journal of Pharmacognosy and Phytochemistry. 2016;5(1):92-101.

Sultana A, Rahman K, Padmaja AR, Rahman S. Boswellia serrata roxb: A traditional herb with versatile pharmacological activity: A review. IJPSR. 2013;4(6):2106-2117

Das DC, Sinha NK, Patsa MK, Das M. Investigation of herbals for the treatment of leucorrhoea from south west Bengal. International Journal of Bioassays. 2015;4(11):4555–4559.

Bajpai O, Pandey J, Chaudhary LB. Ethnomedicinal uses of tree species by Tharu tribes in the Himalayan terai region of India. Research Journal of Medicinal Plant. 2016;10(1):19-41

Alagesaboopathi C. Ethnomedicinal plants and their utilization by villagers in Kumaragiri hills of Salem district of Tamilnadu, India. African Journal of traditional, complementary and alternative Medicines. 2009;6(3):222-227.

Kamboj A, Saluja A. Ageratum conyzoides L.: A review on its phytochemical and pharmacological profile. International Journal of Green Pharmacy. 2008;59-68.

Danish M, Singh P, Mishra G, Srivastava S, Jha KK, Khosa RL. Cassia fistula Linn. (Amulthus)- An Important Medicinal Plant: A Review of Its Traditional Uses, Phytochemistry and Pharmacological Properties. J. Nat. Prod. Plant Resour 2011;1(1):101-118.

Modi AJ, Khadabadi SS, Farooqui IA, Deore SL. Argyreia speciosa linn.f.: phytochemistry, pharmacognosy and pharmacological studies International Journal of Pharmaceutical Sciences Review and Research. 2010;2(2):14- 21.

Sharanappa R, Vidyasagar GM. Plant profile, phytochemistry and pharmacology of Argemone mexicana linn: A review. Int J Pharm Pharm Sci. 2014;6(7):45-53.

Balamurugan S, Vijayakumar S, Prabhu S, Morvin Yabesh JE. Traditional plants used for the treatment of gynaecological disorders in Vedaranyam taluk, South India - An ethnomedicinal survey. J Tradit Complement Med. 2017;8(2):308-323. DOI:10.1016/j.jtcme.2017.06.009.

Chinsembu KC. Ethnobotanical study of medicinal flora utilised by traditional healers in the management of sexually transmitted infections in Sesheke District, Western Province, Zambia. Revista Brasileira de Farmacognosia. 2016;26:268–274.

Orwa C, Mutua A, Kindt R, Jamnadass R, Anthony S. Agroforestree Database: a tree reference and selection guide version 4.0. Agroforestry Database 4.0. 2009;1-5.

Ajibesin KK, Bala DN, Umoh UF. The use of medicinal plants to treat sexually transmitted diseases in Nigeria: Ethnomedicinal survey of Niger Delta Region. Int J Green Pharm. 2011;5:181-91.

Sri PU, Leelavathi V, Manjusha DL, Anusha B, Swapna G. A Comprehensive Review on Hepatoprotective Activity of the Selected Medicinal Plants. IJREAS. 2016;6(7):7-23.

Nyeem MAB, Mannan MA, Nuruzzaman M, Kamrujjaman KM, Das SK. Indigenous king of bitter (Andrographis paniculata): A review. Journal of Medicinal Plants Studies. 2017;5(2):318-324.

Singh AG, Akhilesh K, Tewari DD. An ethnobotanical survey of medicinal plants used in Terai forest of western Nepal. Journal of Ethnobiology and Ethnomedicine. 2012;8(19):1-14.

Adhikari BS, Babu MM, Saklani PL, Rawat GS. Medicinal plants diversity and their conservation status in Wildlife Institute of India (WII) campus, Dehradun. Ethnobotanical Leaflets. 2010;14:46-83.

Vaidya S, Bothra SB. An ethno-phytochemical and pharmacological review on some unexplored medicinal plants belongs to north-east and south-east region of Chhattisgarh. EJPMR. 2014;1(1):240-261.

Chaudhary PH, Khadabadi SS. Bombax ceiba Linn: Pharmacognosy, Ethnobotany and Phyto-pharmacology. Pharmacognosy Communications. 2012;2(3):2-9.

Zhao Y, Kumar Deepak, Prasad DN, Singh RK, Ma Y. Morphoanatomic, physicochemical, and phytochemical standardization with HPTLC fingerprinting of aerial parts of Aerva lanata (Linn) Juss ex Schult. Journal of Traditional Chinese Medical Sciences. 2015;2:39-44.

Upadhyay RK. Ethnomedicinal, pharmaceutical and pesticidal uses of Calotropis procera (Aiton) (Family: Asclepiadaceae). International Journal of Green Pharmacy. 2014;8:135-46.

Younus M. Ethno botanical study and traditional uses of Celastrus paniculatus. IJISET. 2015;2(11):139-143.

Syed I, Fatima H, Abrar M, Siddiqui MA. Ceratophyllum demersum a free-floating aquatic plant: A Review. Indian J .Pharm. Biol. Res. 2018;6(2):10-17.

Bhat MH, Fayaz M, Kumar A, Jain AK. Phytochemical, Pharmacological and Nutritional Profile of Chlorophytum tuberosum (Roxb.) Baker (Safed musli): a Review, International Journal of Theoretical & Applied Sciences. 2018;10(1):93-99.

Marya BH, Bothara SB. Ethnopharmacological properties of Cocculus hirsutus (L.) Diels- a review. International Journal of Pharmaceutical Sciences Review and Research. 2011;7(1):108-112.

Burlia DA, Khade AB. A Comprehensive review on Butea monosperma (Lam.) Kuntze. Pharmacognosy Reviews. 2007;1(2):333-337.

Shivhare Y, Singh P, Singh S, Bharti PK, Tiwari R. Ethanomedicinal Plants for the Prevention and Treatment of Gonorrhea. Research J. Pharm. and Tech. 2011;4(2):182-183.

Nduche MU, Okwulehie IC. Ethnomedicinal Survey Of Plants Used In Treating Sexually Transmitted Diseases In Abia State, Nigeria. Review of Plant Studies. 2014;1(1):1-9.

Gbadamosi IT, Egunyomi A. Ethnobotanical Survey of Plants Used for the Treatment and Management of Sexually Transmitted Infections in Ibadan, Nigeria. Ethnobotany Research & Applications. 2014;12:659-670.

Ramathal DC, Ngassapa OD. Medicinal Plants Used by Rwandese Traditional Healers in Refugee Camps in Tanzania. Pharmaceutical Biology. 2001;39(2):132–137.

Bansal N. Safed musli Chlorophytum borivilianum. MOJ Bioequiv Availab. 2018;5(6):327‒330.

Bizuayehu B, Garedew B. A review on the ethnobotanical study of medicinal plants used for the treatment of Gonorrhea diseases in Ethiopia. Indian Journal of Natural Products and Resources. 2018;9(3):183-193.

Semenya SS, Potgieter MJ, Erasmus LJC. Exotic and indigenous problem plants species used, by the Bapedi, to treat sexually transmitted infections in Limpopo Province, South Africa. African Health Sciences. 2013;13(2):320–326.

Arun Raj GR, Shailaja U, Rao PN, Ajayan S. The therapeutic potential of ten sacred plants (Dashapushpa) of Kerala state of southern India. Journal of Ayurveda and Holistic Medicine. 2013;1(3):22-36.

Jain P, Jain S, Sharma S, Paliwal S. Diverse application of Phoenix sylvestris: A potential herb. Agriculture and Natural Resources. 2018;52:107-114.

Verma SC, Vashishth E, Singh R, Kumari A, Meena AK, Pant P, Bhuyan GC, Padhi MM. A review on parts of Albizia lebbeck (L.) Benth. Used as Ayurvedic drugs. Research J. Pharm. And Tech. 2013;6(11):1235-1241.

Erasmus LJC, Potgieter MJ, Semenya SS, Lennox SJ. Phytomedicine versus Gonorrhea: The Bapedi Experience. Afr J Tradit Complement Altern Med. 2012;9(4):591-598.

Al-Snafi AE. The Constituents and Pharmacology of Corchorus aestuans: A Review. The Pharmaceutical and Chemical Journal. 2016;3(4):208-214.

Jamkhande PG, Barde SR, Patwekar SL, Tidke PS. Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): A review. Asian Pac J Trop Biomed. 2013;3(12):1009-1012.

Subramaniam PA, Velmurugan G, Doss A. Phytochemical and Antimicrobial screening of Ctenolepis garcinii Burm.f – an important medicinal climber. Int. J. Curr. Biotechnol. 2014;2(11):1-4.

DeFilipps RA, Krupnick GA. The medicinal plants of Myanmar. PhytoKeys. 2018;(102):1-341. DOI:10.3897/phytokeys.102.24380.

Acharya R, Jani SV, Harisha CR, Shukla VJ. Phytopharmacognostical investigations on root and stem of Dalbergia volubilis Roxb.: An extrapharmacopoeial plant of Ayurveda. Ayu. 2018;39(3):151–158.

Naidu R, BVA, Rao JK, Reddi TV. Phytotherapy for leucorrhoea from Srikakulam district of Andhra Pradesh. International Multidisciplinary Research Journal. 2011;1/6:14-16.

El-Sharawy RT, Elkhateeb A, Marzouk MM, Abd El-Latif RR, Abdelrazig SE, El-Ansari MA. Antiviral and antiparasitic activities of clovamide: the major constituent of Dichrostachys cinerea (L.) Wight et Arn. Journal of Applied Pharmaceutical Science 2017;7(09):219-223.

Karthika C, Yogeshwari G, Muruganantham K, Manivannan S. Phytochemical Analysis Of Ruellia Patula Using Gas Chromatography Mass Spectrometry. Asian J Pharm Clin Res. 2016;9(2):111-113.

Lande S, Bhogaonkar P. Physical characterisation of Dipteracanthus prostatus (Poir.) Nees a medicinal herb. International Journal of Biology Research. 2018;3(2):60-63.

Sharma A, Mittal A, Aggarwal S, Gupta AK, Sardana S. Evaluation of anti-inflammatory activity of leaves of Eclipta prostrata linn. (Asteraceae). IJPSR. 2011;2(10):2665-2668.

Vasundharan SK, Nair RJ, Annamalai A, Nediya PS. Ethnobotany and distribution status of Ensete superbum (Roxb.) Cheesman in India: A geo-spatial review. Journal of Ayurvedic and Herbal Medicine. 2015;1(2):54-58.

Jain AS, Surana SJ, Gokhale SB, Tatiya AU. Bothara RC. Antimicrobial Properties of Eranthemum roseum (Vahl) R.Br. Iranian Journal of Pharmaceutical Research. 2007;6(2):131-133.

Amritpal Singh. Review of Ethnomedicinal Uses and Pharmacology of Evolvulus alsinoides Linn. Ethnobotanical Leaflets. 2008;12:734-40.

Ateeq A, Maurya SK, Seth A, Singh AK. Pharmacognostical Evaluation of the Fruit of Plaksha - Ficus Lacor Buch. Ham. Global J Res. Med. Plants & Indigen. Med. 2014;3(4):165–174.

Suthar A, Gaja V, Pardeshi Katkar GK, Naik V, Mane T, Kshirsagar R, Vishwakarma R, Chauhan VS. New Naphthalene Derivatives from Heliotropium ovalifolium Forssk. Asian J. Research Chem. 2009;2(4):571-573.

Rajsekhar PB, Bharani RSA, Angel KJ, Ramachandran M, Rajsekhar SPV. Hybanthus enneaspermus (L) F. Muell: A phytopharmacological review on herbal medicine. J. Chem. Pharm. Res. 2016;8(1):351-355.

Sethiya NK, Ahmed NM, Shekh RM, Kumar V, Singh PK, Kumar V. Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (schum.) Hiene: an overview. Journal of Integrative Medicine. 2018;16(5):299-311.

Dahake R, Roy S, Patil D, Chowdhary A, Deshmukh RA. Evaluation of anti-viral activity of Jatropha curcas leaf extracts against potentially drug-resistant HIV isolates. BMC Infect Dis. 2012;12(1):14.

Wang D, Liu K, Guan Y, Ku C, Zhang H. Isolation of bioactive chemical constituents from Justicia procumbens. Planta Med. 2015;81:14.

Dashora N, Chauhan S, Kumar N. Luffa acutangula (Linn.) Roxb. var. amara (roxb.) a consensus review. Int J Pharm Bio Sci. 2013;4(2):835–846.

Tripathi IP, Chaudhary P, Pandey P. Mallotus Philippensis: A Miracle Stick. World Journal of Pharmaceutical Research. 2017;6(7):678-687.

Shah KA, Patel MB, Patel RJ, Parmar PK. Mangifera Indica (Mango). Pharmacognosy Reviews. 2010;4(7):42-48.

Kadam PV, Yadav KN, Deoda RS, Shivatare RS, Patil MJ. Mimusops elengi: A Review on Ethnobotany, Phytochemical and Pharmacological Profile. Journal of Pharmacognosy and Phytochemistry. 2012;1(3):64-74.

Sathiyanarayanan L, Arulmozhi S. Mucuna pruriens Linn. - A Comprehensive Review. Pharmacognosy Reviews. 2007;1(1):157-162.

Pandya DJ, Anand IS. A Complete Review on Oxystelma esculentum R. Br. Pharmacognosy Journal. 2011;3(19):87-90.

Ramoji A, Kuppast IJ, Mankani KL. Phytochemical screening and In vitro antioxidant activity of Paracalyx scariosa (Roxb) Ali. IJPSR. 2014;5(6):269-274.

Dandge PB, Karajagi AB, Bhagwat PK, Bhise KK. Phytochemical profiling and antimicrobial potential of Santalum album, Morinda citrifolia and Mucuna pruriens. RJLBPCS. 2016;1(5):265-271.

Veda GP, Rao BG, Swathi K, Priya K. Antioxidant activity of Soymida Febrifuga Roxb. A. Juss. IJPSR. 2014;5(5):1847-1851.

Chattopadhyay RR, Bhattacharyya SK. Terminalia chebula: An update. Pharmacognosy Reviews. 2007;1(1):151-156.

Sukalingam K, Ganesan K, Ponnusamy K, Ponnusamy SV. Pharmacological Properties of Trianthema portulacastrum L and its Therapeutic Potential as Complementary Medicine. International Journal of Pharmaceutical and Chemical Sciences. 2015;4(2):269-274.

Choudhari NB, Khade RS, Thakare IS. In vitro Medicinal plant Uraria picta Jacq DC. Int. J. Adv. Res. Biol. Sci. 2020;7(4):169-172.

Chowdhury MA, Rahman MM, Chowdhury MRH, Uddin MJ, Sayeed MA, Hossain MA. Antinociceptive and cytotoxic activities of an epiphytic medicinal orchid: Vanda tessellata Roxb. BMC Complementary and Alternative Medicine. 2014;14:464.

Patel BP and Singh PK. Viscum articulatum Burm. f.: A review on its phytochemistry, pharmacology and traditional uses. Journal of Pharmacy and Pharmacology. 2018;70:159– 177.