Acalypha indica L. - an Important Medicinal Plant: A Brief Review of Its Pharmacological Properties and Restorative Potential
European Journal of Medicinal Plants,
Medicinal plants are moving from border to mainstream use with a more number of people seeking treatment and health approaches free from side effects caused by synthetic chemicals. India officially recognizes over 3500 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in folk, traditional and herbal medicine. This review article aims to provide a comprehensive review on the phytochemical and various pharmacological aspects of Acalypha indica. This plant widely used in traditional medicinal system of India and many other countries has been reported to possess anti-cancer, anti-diabetic, anti-oxidant, anti-bacterial, antifungal hepatoprotective, anti-inflammatory, and also used to check anti-ulcers and wounds healing. It is known as a rich source of glycosides, flavanoids and tannins. The medicinal properties and therapeutic uses of Acalypha indica and its secondary metabolites investigations prove its importance as a valuable medicinal plant.
- Acalypha indica
- wounds healing
How to Cite
Chekuri S, Rao NB, Panjala S, Vankudothu N, Anupalli RR. Phytochemical analysis, anti-oxidant and anti-microbial activity of “Acalypha indica” leaf extracts in different organic solvents. International Journal of Phytomedicine. 2016;8:444-452. (IF:1.23)
Martin GJ. Ethnobotany-A people and plants conservation manual. Parthenon Publishing Group Casterton Hall, Carnforth Lancashire, England; 1995.
Dineshkumar B, Vigneshkumar P, Bhuvaneshwaran S, Analava M. Phytopharmacology of Acalypha indica: A review. International Journal of BioSciences, Alternative and Holistic Medicine (IJBSAHM). 2010;1:27-32.
Sivasankari B, Anandharaj M, Gunasekaran P. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India. J. Ethnopharmacol. 2014;153:408-423.
Kirtikar KRB, Baman D. Indian medicinal plants. Indian Medicinal Plants. Saha R, Ahmed A, 2011b. Phytochemical constituents and pharmacological activities of Acalyphus Indica Linn: A review. International Journal of Pharmaceutical Sciences Research. 1918;2:1900-1904.
Savithramma N, Sulochana C, Rao K. Ethnobotanical survey of plants used to treat asthma in Andhra Pradesh, India. J. Ethnopharmacol. 2007;113:54-61.
Scaffidi A, Algar D, Bohman B, Ghisalberti EL, Flematti G. Identification of the cat attractants isodihydronepetalactone and iso iridomyrmecin from Acalypha indica. Aust. J. Chem. 2016;69:169- 173.
Marwah RG, Fatope MO, Al Mahrooqi R, Varma GB, Al Abadi H, Al-Burtamani SKS. Antioxidant capacity of some edible and wound healing plants in Oman. Food Chem. 2007;101:465-470.
Burkill HM. The useful plants of west tropical Africa. Volume 2: Families EI. Botanic Gardens; 1994.
Takle V, Savad R, Kandalkar A, Akarte A, Patel A. Pharmacognostic and phyto-chemical investigations of aerial parts of Acalypha indica Linn. Pharmacognosy Journal. 2011;3:33-35.
Joy B, Mathew M, Awaad A, Govil J, Singh V. Anti-oxidant studies and chemical investigation of ethanol extract of Acalypha indica Linn. Drug Plants. 2010;1:261-279.
Sanseera D, Niwatananun W, Liawruangrath B, Liawruangrath S, Baramee A, Trisuwan K, Pyne SG. Antioxidant and anticancer activities from aerial parts of Acalypha indica Linn. Chiang Mai University Journal of Natural Sciences. 2012;11(2):157- 168.
Rahman MA, Bachar SC, Rahmatullah M. Analgesic and anti-inflammatory activity of methanolic extract of Acalypha indica Linn. Pak. J. Pharm. Sci. 2010;23:256-258.
Vogel H. Drug discovery and evaluation: Pharmacological assays. Springer Science & Business Media; 2007.
Crunkhorn P, Meacock S. Mediators of the inflammation induced in the rat paw by carrageenin. Br. J. Pharmacol. 1971;42: 392-402.
Chengaiah B, Kumar MK, Alagusundaram M, Sashikala C, Chetty MC. In vitro anthelmintic activity of roots of Acalypha indica Linn. International Journal of Pharm Tech Research. 2009;1:1499-1502.
Ranju G, Niranjan S, Kumar PS, Kumar PV, Kumar PS. In vitro anthelmintic activity of Acalypha indica leaves extracts. International Journal of Research in Ayurveda and Pharmacology. 2011;2:247-249.
Junior A, Zanil C. Biological screening of Brazilian meditational plants. Braz. J. Sci. 2000;367-373.
Batubara I, Wahyuni WT, Firdaus I. Utilization of Anting-Anting (Acalypha indica) leaves as antibacterial. IOP Conference Series: Earth and Environmental Science. IOP Publishing. 2016;012038.
Amarnath K, Dhanabal J, Agarwal I, Seshadry S. Cytotoxicity induction by ethanolic extract of Acalypha indica loaded casein-chitosan microparticles in human prostate cancer cell line in vitro. Biomedicine & Preventive Nutrition. 2014;4:445-450.
Chekuri S, Panjala S, Anupalli RR. Cytotoxic activity of Acalypha indica L. hexane extract on breast cancer cell lines (MCF-7). The International Journal of Phytopharmacology (Pharmacognosy and Phytomedicine) research. 2017;6(5):264-268.
Wang D, Zhang S, Chang Z, Kong D-X, Zuo Z. Quebrachitol: Global status and basic research. Natural Products and Bioprospecting. 2017;1-10.
Nandhakumar M, Tamil Iniyan G, Senthilkumar M, Dineshkumar B, Mitra A. In vitro assay of alpha amylase inhibitory activity of Indian medicinal herb Acalypha indica. J. Clin. Diagn. Res. 2009;3:1475-1478.
Chopra R, Nayar SI, IC C. Glossary of Indian Medical Plants, New Delhi, India; 1956.
Hungeling M, Lechtenberg M, Fronczek FR, Nahrstedt A. Cyanogenic and noncyanogenic pyridoneglucosides from Acalypha indica (Euphorbiaceae). Phytochemistry. 2009;70:270-277.
Selvamani S, Balamurugan S. Antibacterial and antifungal activities of different organic solvent extracts of Acalypha indica (Linn.). Asian Journal of Plant Science and Research. 2015;5:52-55.
Sakthi SS, Geetha M, Saranraj P. Pharmacological screening of Datura metel and Acalypha indica for its antifungal activity against pathogenic fungi. International Journal of Pharmaceutical Science and Health Care. 2011;2:15- 30.
Hnatyszyn O, Juárez S, Ouviña A, Martino V, Zacchino S, Ferraro G. Phytochemical analysis and antifungal evaluation of Sebastiania commersoniana extracts. Pharm. Biol. 2007;45:404-406.
Soruba E, Sundaram V, PathyManian R, Kulanthaivelu K, Balasundaram S. Antioxidant, antibacterial and anti-inflammatory activity of Acalypha indica and Terminalia chebula: An In-vitro analysis. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2015;6:180.
Muzammil MS, Manikandan M, Jafar A, Sakthivel P, Geetha S, Malarkodi R. Anti-inflammatory studies on Acalypha indica L. leaves by membrane stabilization. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]. 2015;5:195-197.
Rajasekaran S, Anandan R, Nishad K. Antihyperlipidemic activity of Acalypha indica Linn. onatherogenic diet induced hyperlipidemia. Int. Jour of Pharm. & Pharm. Sci. 2013;5:699-701.
Moon J, Do H-J, Kim OY, Shin M-J. Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats. Food Chem. Toxicol. 2013;58:347-354.
Ruslan NF. Evaluation of Acalypha indica extracts for antioxidant and antibacterial activities. Department of Biosciences and Health Sciences. Universiti Teknologi Malaysia; 2015.
Kalimuthu S, Rajesh P, Kannan VR, Balamurugan B, Chandrasekar T. Antiulcer activity of methanolic extract of Acalypha indica Linn. (Euphorbiaceae) by pylorousligture and swim stress induced ulceration. Journal of Pharmacy Research. 2010;3:2779-2783.
Shirwaikar A, Rajendran K, Bodla R, Kumar CD. Neutralization potential of Viper R sselli R sselli (R ssell’s viper) venom by ethanol leaf extract of Acalypha indica. J. Ethnopharmacol. 2004;94:267-273.
Rajendran K, Shirwaikar A, Mehta M, Bharathi RV. In vitro and in vivo anti-snake venom (Daboia russelli) studies on various leaf extracts of Acalypha indica Linn. International Journal of Phytomedicine. 2010;2.
Alam MI, Gomes A. Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R. BR) root extract. Toxicon. 1998;36:207-215.
McDiarmid RW, Campbell JA, Touré T. Snake species of the world: A taxonomic and geographic reference. 1999;1.
Ali AM, Mackeen MM, El-Sharkawy SH, Abdul Hamid J, Ismail NH, Ahmad F, Lajis MN. Antiviral and cytotoxic activities of some plants used in Malaysian indigenous medicine. Pertanika Journal of Tropical Agricultural Science. 1996;19:129-136.
Reddy JS, Rao PR, Reddy MS. Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats. J. Ethnopharmacol. 2002;79:249-251.
Ibrahim AM. In vitro evaluation and wound healing cream formulation of Acalypha indica Linn ethanolic extract. Department of Biosciences and Health Sciences. Universiti Teknologi Malaysia; 2016.
Ganeshkumar M, Ponrasu T, Krithika R, Iyappan K, Gayathri VS, Suguna L. Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of type I and III collagen. J. Ethnopharmacol. 2012;14:214-22.
Naik R, Nemani H, Pothani S, Pothana S, Satyavani M, Qadri SS, Srinivas M, Parim B. Obesity-alleviating capabilities of Acalypha indica, Pergularia demia and Tinospora cardifolia leaves methanolic extracts in WNIN/GR-Ob rats. Journal of Nutrition & Intermediary Metabolism. 2019;16:100090.
Abstract View: 3520 times
PDF Download: 3433 times