Aloe vera (L.) Burm. F. as a Potential Anti-COVID-19 Plant: A Mini-review of Its Antiviral Activity

Main Article Content

Pius T. Mpiana
Koto-Te-Nyiwa Ngbolua
Damien S. T. Tshibangu
Jason T. Kilembe
Benjamin Z. Gbolo
Domaine T. Mwanangombo
Clement L. Inkoto
Emmanuel M. Lengbiye
Clement M. Mbadiko
Aristote Matondo
Gedeon N. Bongo
Dorothée D. Tshilanda


Aims: A novel β-coronavirus (2019-nCoV) has become a pandemic affecting hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods which can help to curb this pandemic is urgent. This study aims to review the literature on the virucidal and cytotoxic properties of Aloe vera, one of the most studied plants considered as a nutraceutical in order to propose it as an alternative solution against COVID-19.

Methodology: The literature review was based mainly on the COVID-19 resources that have been made freely available to the scientific community but also on the usual databases such as Pubmed and Google scholar.

Results: The literature review shows that the plant has antiviral activity on several types of virus (Haemorrhagic Viral Rhobdavirus Septicaemia, Herpes simplex virus type 1, Herpes simplex virus type 2, Varicella-Zoster virus, human immunodeficiency virus, Influenza virus, poliovirus, Cytomegalovirus, Human papillomavirus) including coronavirus SARS-CoV-1. The plant is consumed orally in several forms and is safe. It is possible that  molecules of this plant that have already shown effectiveness on other viruses by some mechanisms such as interaction of virus enzyme, breakdown of the viral envelope etc. could participate in the action of the plant. Also, the presence of minerals such as Zinc, which have shown an effect on SARS-CoV-1, could be involved in the antiviral effect of Aloe vera.

Conclusion: Molecular docking of the main molecules of Aloe vera with SARS-CoV-2 protease is in progress and clinical trials are necessary to confirm the activity of Aloe vera on COVID-19.

Aloe vera, COVID-19, antiviral activity, molecular docking, sars-cov-2.

Article Details

How to Cite
Mpiana, P. T., Ngbolua, K.-T.-N., Tshibangu, D. S. T., Kilembe, J. T., Gbolo, B. Z., Mwanangombo, D. T., Inkoto, C. L., Lengbiye, E. M., Mbadiko, C. M., Matondo, A., Bongo, G. N., & Tshilanda, D. D. (2020). Aloe vera (L.) Burm. F. as a Potential Anti-COVID-19 Plant: A Mini-review of Its Antiviral Activity. European Journal of Medicinal Plants, 31(8), 86-93.
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Di W, Tiantian W, Qun L, Zhicong Y. The SARS-CoV-2 outbreak: what we know; 2020. Available:

Peeri NC, Shrestha N, Rhaman MS, Zaki R, Tan Z, Bibi S, et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int Journal of Epidemiology. 2020;1-10.

Zheng J. SARS-CoV-2: An emerging coronavirus that causes a global threat. Int J of Biol Sci. 2020;16(10):1678-1685.

Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ et al. Research and development on therapeutic agents and vaccines for COVID-19 and related human Coronavirus diseases. ACS Cent Sc. 2020; 25(6):315-331.

Cao B, Wang Y, Wen D. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med; 2020.
DOI: 10.1056/NEJMoa2001282. 32187464

Sarma P, Prajapat M, Medhi B. Therapeutic options for the treatment of 2019-novel coronavirus: An evidence-based approach. Indian J of Pharmacol. 2020;52(1):1-5.

Chong YP, Song JY, Seo YB, Choi JP, Shin HS. Antiviral treatment guidelines for middle east respiratory syndrome. Infection and Chemotherapy. 2015;47(3):212- 222.

Andrea C, Giulia I, Mariachiara I, Antonino G, Sharon E. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19; 2020.

Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends; 2020.

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res; 2020.

Li-sheng W, Yi-ru W, Da-wei Y, Qing-quan L. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. International Journal of Antimicrobial Agents; 2020.

Mpiana PT, Mudogo V, Tshibangu DST, Kitwa EK, Kanangila AB, Lumbu JBS, et al. Antisickling activity of anthocyanins from Bombax pentadrum, Ficus capensis and Ziziphus mucronata: Photodegradation effect. J. Ethnopharmacology. 2008;120: 413-418.

Tshilanda DD, Onyamboko DNV, Babady BP, Mutwale KP, Tsalu VP, Tshibangu DST, et al. Chemical fingerprint and anti-sickling activity of Rosmarinic acid and Methanolic extracts from three Species of Ocimum from DR Congo. Journal of Biosciences and Medicines. 2016;4:59-68.

Tshilanda DD, Onyamboko DNV, Babady PB, Ngbolua KN, Tshibangu DST, Dibwe EF et al. Anti-sickling activity of ursolic acid isolated from the leaves of Ocimum gratissimum L. (Lamiaceae). Nat. Prod. Bioprospect. 2015;5:215-221.
DOI: 10.1007/s13659-015-0070-6

Inkoto LC, Bongo NG, Kapepula MP, Masengo AC, Gbolo ZB, Tshiama C, et al. Microscopic features and chromatographic fingerprints of selected congolese medicinal plants: Aframomum alboviolaceum (Ridley) K. Schum, Annona senegalensis Pers. and Mondia whitei (Hook.f.) Skeels. Emergent Life Sciences Research. 2018;4(1):1-10.

Ipona EN, Inkoto CL, Bongo GN, Mulenga CM, Ilinga BL, Shetonde OS, et al. Ethno-botanical survey and ecological study of medicinal plants traditionally used against erectile dysfunction in Democratic Republic of the Congo; Bioscience and Bio-engineering. 2019;4(4):85-91.

Ngbolua KN, Mpiana PT, Mudogo V. Pharmacopée traditionnelle et lutte contre la drépanocytose: Méthodes de sélection et d’évaluation de l’activité des plantes médicinales. Editions Universitaires Européennes, Riga: Latvia; 2019.

Kroll DJ. Concerns and needs for research in herbal supplement pharmacotherapy and safety. J. Herbal Pharmather. 2001; 1(2):3-23.

Olamide EA, Abatan MO. Phytochemical and acute toxicity of ethanolic extract of Enantia chlorantha (oliv) stem bark in albino rats. Interdiscip Toxicol. 2013;6(3): 145-151.
DOI: 10.2478/intox-2013-0023

Mukherjee PK, Nema NK, Maity N, Mukherjee K, Harwansh RK. Phyto-chemical and therapeutic profile of Aloe vera. Journal of Natural Remedies. 2014; 14(1):1-26.

The plant list, accessed 18/04/2020 Available:

Zandi K, Zadeh MA, Sartavi K, Rastian Z. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. Afr J Biotechnol. 2007;6:1770- 1773.

Singh S, Sharma PK, Kumar N, Dudhe R. Biological activities of Aloe vera. Int. J. Pharm. Technol. 2010;2(3):259-580.

Sharrif MM, Sandeep KV. Aloe vera their chemicals composition and applications: A review. Int J Biol Med Res. 2011;2(1):466-471.
Anonymous. Accessed on 18/04/2020

COVID-19 open research dataset accessed on 17/04/2020.

Morin E. Aloe vera (L.) Burm.f.: Aspects pharmacologiques et cliniques. Thèse de doctorat en pharmacie, Faculté de Pharmacie, Université de Nantes. 2008; 224.

Alves DS, Pêrez-Fons L, Estepa A, Micol V. Membrane-related effects underlying the biological activity of the anthraquinones emolin and barbaloin. Biochemical pharmacology. 2004;68:549-561.

Keivan Z, Moloud AZ, Kohzad S, Zahra R. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. African Journal of Biotechnology. 2007;6(15):1770-1773.

Jang-Gi C, Heeeun L, Young SK, Youn-Hwan H, You-Chang O, Bonggi L, et al. Aloe vera and its Components Inhibit Influenza A Virus-Induced Autophagy and Replication. The American Journal of Chinese Medicine. 2019;47(6):1–18.

Kahlon JB, Kemp MC, Carpenter RH, McAnalley BH, McDaniel HR, Shannon WM. Inhibition of AIDS virus replication by acemannan in vitro. Mol Biother. 1991;3: 127-35.

McGuffin M, Hobbs C, Upton R, Goldberg A. American herbal products association's botanical safety handbook. Boca Raton. New York: CRC Press. 1997;231.

Bernard DL, Huffman JH, Morris JL, Wood SG, Hughes BG, Sidwell RW. Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. Antiviral. Res. 1992;35:2463-2466.

Semple SJ, Pyke SM, Reynolds GD, Flower RL. In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral. Res. 2001;49:169-178.

Zandi K, Zadeh MA, Sartavi K, Rastian Z. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. Afr J Biotechnol. 2007;6:1770-1773.

Kuo PL, Lin TC, Lin CC. The anti-proliferative activity of aloe-emodin is through P53-dependent and P21 apoptotic pathway in human hepatoma cell lines. Life Sciences. 2002;71:1879-1892.

Rezazadeh F, Moshaverinia M, Motamedifar M, Alyaseri M. Assessment of Anti HSV-1 activity of Aloe vera gel extract: an in vitro study. J Dent Shiraz Univ Med Sci. 2016;17:49-54.

Wynn RL. Aloe vera gel: Update for dentistry. General Dentistry. 2005;53:6-9.

Iljazović E, Ljuca D, Sahimpasić A, Avdić S. Efficacy in treatment of cervical HRHPV infection by combination of beta interferon, and herbal therapy in woman with different cervical lesions. Bosn J Basic Med Sci. 2006;6(4):79-84.

Arunkumar S, Muthuselvam M. Analysis of phytochemical constituents and anti-microbial activities of Aloe vera L. against clinical pathogens. World Journal of Agricultural Sciences. 2009;5(5):572-576.

Femenia A, Sanchez ES, Simal S, Rosello C. Compositional features of polysac-charides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr. Polym. 1999;39:109-117.

Aartjan te Velthuis JW, Sjoerd van den Worm HE, Amy Sims C, Baric RS, Snijder EJ, Van Hemert MJ. Zn2+ Inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. Plos Pathogens. 2010;6(11):1-10,e1001176.

Du Plessis LH, Hamman JH. In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials. Drug Chem Toxicol. 2014;37:169–177.

Shao A, Broadmeadow A, Goddard G, Bejar E, Frankos V. Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm. f. juice in a 3- month drinking water toxicity study in F344 rats. Food Chem Toxicol. 2013;57:21– 31.

Saritha V, Anilakumar KR. Toxicological evaluation of methanol extract of Aloe vera in rats. IJPBR. 2010;1(5):142-149.

Sehgal I, Winters WD, Scott M, David A, Gillis G, Stoufflet T, et al. Toxicologic assessment of a commercial decolorized whole leaf Aloe vera juice, lily of the desert filtered whole leaf juice with aloe sorb. J Toxicol. 2013;1-12.

Li-sheng W, Yi-ru W, Da-wei Y, Qing-quan L. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. International Journal of Antimicrobial Agents; 2020.

Bhalsinge RR, Rajbhoj SR, Limaye MV, Vaidya MU, Rane PS, Tilak AV. Anti-inflammatory and Immunomodulatory activity of ethanol extract of Aloe vera gel. IJPSR. 2017;9(2):832-835.