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Leptadenia pyrotechnica is fibre yielding plant and member of Asclepiadaceae family. Commonly all parts of Leptadenia pyrotechnica are used in folk medicines by local people. The present study gives qualitative estimation of alkaloids and its pharmacological properties. The qualitative and analysis of alkaloids carried out by using GCMS and spectral studies. Antimicrobial properties evaluate by well diffusion method. Fifty compounds found in GCMS analysis of shoots of Leptadenia pyrotechnica á,á Carotene, 6',7'-didehydro-5,6-epoxy-5,5', 6,6',7,8hexahydro3,3', 5'trihydroxy8oxo (3.56%) found to be maximum area observed at the retention time of 28.15. Shoots and roots both showed remarkable antimicrobial activity against selected microbial agents. Maximum zone of inhibition was observed in roots (15 mm) against Staphylococcus aureus and in fungal strains shoot showed (17 mm) zone of inhibition against Penicillium funiculosum. The findings of this study illustrate that Leptadenia pyrotechnica have remedial capability.
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