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Dendrophthoe falcata (L.f.) Ettingsh is an important medicinal plant belonging to the family Loranthaceae. It is perennial, climbing and woody parasitic plant of family Loranthaceae. It is ethnomedicinally used for treating ulcers, asthma, impotence, paralysis skin diseases and wounds. In the present study, an attempt was made to investigate the phytochemical constituents present in the Dendrophthoe falcata (L.f.) Ettingsh stem. The preliminary phytochemical screening in different solvents extract was done by using standard methods. The phytochemical screening revealed the presence of carbohydrates, protein and amino acids, fixed oils and fats, saponins, sterols, alkaloids, phenols, tannins, flavonoids, anthocyanin and anthraquinones in different solvent extracts. GC-MS analysis was performed on the methanolic extract to find out the chemical constituents. The GC-MS study revealed the presence of about 51 bioactive compounds. Cyclopentasiloxane, Cyclohexasiloxane, Cycloheptasiloxane, Cyclooctasiloxane, Cyclononasiloxane, Phthalic acid, Hexadecanoic acid, Cyclodecasiloxane, Cyclononasiloxane, Tetracosane, Tetratriacontane, Benzoic acid, 1-Monolinoleoylglycerol trimethylsilyl ether, Octadecane, ç-Sitosterol are some of the major phytoconstituents reported from the sample. Further research work is needed on these identified compounds to analyse their mode of action and usefulness in phytopharmaceutical industries.