In silico Analysis of Phytochemicals from Cocoa against Ribitol-5-Phosphate 2-Dehydrogenase of Streptococcus pneumoniae Causing Pneumonia

Main Article Content

Sunanya Das
Suchismita Khatei
Saismita Sahoo
Sitaram Swain
Dipankar Bhattacharyay

Abstract

This analysis aims at evaluating the effects of Cocoa extract on Pneumonia. Pneumonia is caused by Streptococcus pneumoniae. Caffeine, Chorogenic acid, Ferulic acid, Iso- Orientin, luteolin, Naringenin and Vanillic acid of Cocoa were interacted with ribitol-5-phosphate 2-dehydrogenase which is involved in pentose and glucorunate interconversion pathways of Streptococcus pneumoniae. The enzyme was taken as receptor and phytochemicals were considered as ligands. All the interactions were done in Biovia discovery Studio 2020 and the process is known as molecular Docking. Molecular Docking provides us an opportunity to identify the potential phytochemical or component which can act as powerful tool against the pathogen. Out of all the phytochemicals, Luteolin of Cocoa inhibits or blocks the mechanism or action of ribitol-5-phosphate 2-dehydrogenase enzyme of Streptococcus pneumoniae. There is high possibility that these phytochemicals can potentially inhibit others enzymes involved in various metabolic pathways of Streptococcus pneumoniae.

Keywords:
Phytochemical, biovia discovery studio 2020, cocoa, metabolic pathways, pneumonia, Streptococcus pneumonia.

Article Details

How to Cite
Das, S., Khatei, S., Sahoo, S., Swain, S., & Bhattacharyay, D. (2020). In silico Analysis of Phytochemicals from Cocoa against Ribitol-5-Phosphate 2-Dehydrogenase of Streptococcus pneumoniae Causing Pneumonia. European Journal of Medicinal Plants, 31(6), 1-5. https://doi.org/10.9734/ejmp/2020/v31i630240
Section
Original Research Article

References

Lee KW, Kim YJ, Lee HJ, Lee CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. Journal of Agricultural and Food Chemistry. 2003;51(25):7292-7295.

Subhashini R, Rao UM, Sumathi P, Gunalan G. A comparative phytochemical analysis of cocoa and green tea. Indian Journal of Science and Technology. 2010; 3(2):188-192.

Shahanas E, Seeja T, Panjikkaran ER, Aneena CL, Sharon, Remya PR. Health benefits of bioactive compounds from cocoa (Theobroma cacao). Agricultural Reviews. 2019;40(2):143-149.

Kim J, Lee KW, Lee HJ. Cocoa (Theobroma cacao) seeds and phyto-chemicals in human health. In Nuts and seeds in health and disease prevention. Academic Press. 2011;351-360.

InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Pneumonia: Overview. 2018;9.
Available:https://www.ncbi.nlm.nih.gov/books/NBK525774/

Lateef Agbaje, Musibau A. Azeez, Tesleem B. Asafa, Taofeek A. Yekeen, Akeem Akinboro, Iyabo C. Oladipo, Luqmon Azeez, Sunday A. Ojo, Evariste B. Gueguim-Kana, Lorika S. Beukes. Cocoa pod husk extract-mediated biosynthesis of silver nanoparticles: Its antimicrobial, antioxidant and larvicidal activities. Journal of Nanostructure in Chemistry. 2016;6(2): 159-169.

Chawla K, Gurung B, Mukhopadhyay C, Bairy I. Reporting emerging resistance of Streptococcus pneumoniae from India. Journal of Global Infectious Diseases. 2010;2(1):10.

Baur Stefanie, Jon Marles-Wright, Stephan Buckenmaier, Richard J. Lewis, Waldemar Vollmer. Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae. Journal of Bacteriology. 2009;191(4):1200-1210.

Nayak Subhalaxmi, Dibyabhaba Pradhan, Harpreet Singh, Sudhakara Reddy M. Computational screening of potential drug targets for pathogens causing bacterial pneumonia. Microbial pathogenesis. 2019; 130:271-282.

Brinda OP, Deepu Mathew, Shylaja MR, Sangeetha Davis P, Anita Cherian K, Valsala PA. isovaleric acid and avicequinone-C are chikungunya virus resistance principles in Glycosmispenta-phylla (Retz.) Correa. 2019;56(2):111-121.

Scapagnini G, Davinelli S, Di Renzo L, De Lorenzo A, Olarte HH, Micali G, Gonzalez S. Cocoa bioactive compounds: Signifi-cance and potential for the maintenance of skin health. Nutrients. 2014;6(8):3202-3213.

Moorhead ES. The treatment of pneumonia. Canadian Medical Association Journal. 1930;22(5):669.