Chemistry of California Lycium cooperi and Lycium andersonii

Main Article Content

Gerson Navarrete
Axel Bracquemond
Enrique Villasenor
Michelle Wong
James Adams


Aims: To examine the chemistry of two California Lycium species and evaluate the possible use of California Lycium species as dietary supplements especially for age related macular degeneration.

Study Design: This exploratory analytical research used samples of Lycium andersonii and Lycium cooperi collected in the field and analyzed in the lab.

Place and Duration of Study: University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA USA 90089.

Methodology: Plant extracts were analyzed by high pressure liquid chromatography mass spectrometry with ultraviolet photodiode array detection in order to identify the chemical characteristics of compounds found in the plants.

Results: Several known compounds were found in extracts of Lycium cooperi and Lycium andersonii foliage and fruit including: zeaxanthin, zeaxanthin monopalmitate and β-cryptoxanthin.  The various California species of Lycium are discussed as possible alternatives to Chinese Lycium barbarum.

Conclusion: California Lycium berries may be suitable substitutes for Chinese Lycium berries.

Age related macular degeneration, Lycium, Lycium andersonii, Lycium cooperi, zeaxanthin.

Article Details

How to Cite
Navarrete, G., Bracquemond, A., Villasenor, E., Wong, M., & Adams, J. (2019). Chemistry of California Lycium cooperi and Lycium andersonii. European Journal of Medicinal Plants, 29(3), 1-5.
Original Research Article


He M, Chang F, Lin H, Wu J, Hsieh T, Lee Y. The association between diabetes and age-related macular degeneration among the elderly in Taiwan. Diabetes Care. 2018;41:2202-2211.

Adams J, Parker K. Extracellular and intracellular signaling. Royal Society of Chemistry, London; 2011.

Lim L, Mitchell P, Seddon J, Holz F, Wong T. Age-related macular degeneration. Lancet. 2012;379:1728-38.

Ong B, Ah-Fat F. Age-related macular degeneration. British Journal of Hospital Medicine. 2016;77:C18-C21.

Gao Y, Wei Y, Wang Y, Gao F, Chen Z. Lycium barbarum: A traditional Chinese herb and a promising anti-aging agent. Aging and Disease. 2017;8:778-91.

Wolfberry festival to be held in Ningxia. China Daily; 2004.

Baldwin B, Goldman D, Keil D, Patterson R, Rosatti T, Wilkin D. The Jepson manual vascular plants of California, Second Edition. University of California Press, Berkeley. 2012;1252-3.

Strike S. Ethnobotany of the California Indians. Aboriginal uses of California’s indigenous plants. Koeltz Scientific Books, Champaign. 1994;2:87.

Moerman D. Native American ethno-botany. Timber Press, Portland; 1998.

Bean L, Saubel K. Temalpakh. Cahuilla Indian knowledge and usage of plants. Malki Museum Press, Morongo Indian Reservation; 1972.

Sarungallo Z, Harivadi P, Andarwulan N, Purnomo E, Wada M. Analysis of α-cryptoxanthin, β-cryptoxanthin, α-carotene, and β-carotene of Pandanus conoideus oil by high-performance liquid chromatography (HPLC). Procedia Food Science. 2015;3:231-243.

Niro S, Fratianni A, Panfili G, Falasca L, Cinquanta L, Rizvi Alam M. Nutritional evaluation of fresh and dried goji berries cultivated in Italy. Italian Journal of Food Science. 2017;29:398-408.

Franke D, Lai J, Halm B. Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake. Archives of Biochemestry and Biophysics. 2014;559: 24-28.

Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Archives of Ophthalmology. 2001;119:1417–1436.

Karp D. Goji taunts North American farmers. Los Angeles Times; 2009.

Spurrier J. Super goji berry takes care to grow. Los Angeles Times; 2013.

O'Neil M. The Merck index - an encyclopedia of chemicals, drugs, and biologicals. Merck and Co, Whitehouse Station. 2006;913.

Qian D, Zhao Y, Yang G, Huang L. Systematic review of chemical constituents in the genus Lycium (Solanaceae). Molecules. 2017;22:911-34.

Zhou Z, Fan H, He R, Xiao J, Tsoi B, Lan K, Kurihara H, So K, Yao X, Gao H. Lycibarbarspermidines A-O, new dicaffeoylspermidine derivatives from wolfberry, with activities against Alzheimer's disease and oxidation. Journal of Agricultural and Food Chemistry. 2016;64:2223-37.

Wells J, Cole R, Kirksey J. Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts. Applied Microbiology. 1975;30:26-28.

Yahara S, Shigeyama C, Ura T, Wakamatsu K, Yasuhara T, Nohara T. Cyclic peptides, acyclic diterpene glyco-sides and other compounds from Lycium chinense Mill. Chemical and Pharmaceutical Bulletin (Tokyo). 1993;41: 703-9.

Sajilata M, Singhal R, Kamat M. The carotenoid pigment zeaxanthin - a review. Comprehensive Reviews in Food Science and Food Safety. 2008;7:29-49.

Saeidnia S, Manayi A, Gohari A, Abdollahi M. The story of beta-sitosterol-a review. European Journal of Medicinal Plants. 2014;4:590-609.
NIST Chemistry Web Book, SRD 69; 2019. (Accessed September 2019)